A chronic, systemic infectious disease caused by Treponema pallidum
Transmitted sexually by direct contact with an active lesion, vertically (maternal–fetal), and via blood transfusio...
As a “great imitator,” a high index of suspicion is often required for accurate diagnosis.
Previous sexual contact with partner with known infection or high-risk sexual behavior
Advise patients to notify partner(s) and to avoid intercourse until treatment is complete (5)[A].
Test for HIV infection (3),(5)[A].
Management of sexual contacts (5)[A]
Clinical and serologic evaluation 6 to 12 months after treatment; if >1 year duration, check at 24 months (5)[A].
In HIV-infected persons, clinical and serologi...
A53.9 Syphilis, unspecified
A51.0 Primary genital syphilis
A53.0 Latent syphilis, unspecified as early or late
A51.5 Early syphilis, latent
A52.9 Late syphilis, unspecified
A51.49 Other secondar...
Screen all HIV-positive patients and patients with high-risk sexual behaviors for syphilis.
Penicillin remains the treatment of choice for syphilis.
Syphilis rates are rising—particularl...
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