A chronic, systemic infectious disease caused by the spirochete Treponema pallidum
Transmitted sexually by direct contact with an active lesion. Also transmitted vertically (maternal–...
As a “great imitator,” a high index of suspicion is often required for accurate diagnosis.
Previous sexual contact with partner with known infection or high-risk sexual behavior
Genital...
Advise patients to notify partner(s) and to avoid intercourse until treatment is complete (1)[A].
Test for HIV infection.
Management of sexual contacts (3)[A]
Presumptiv...
Clinical and serologic evaluation 6 to 12 months after treatment; if >1 year duration, check at 24 months (3)[A].
In PLWH, clinical and serologic evaluation at...
A52.71 Late syphilitic oculopathy
A51.0 Primary genital syphilis
A52.74 Syphilis of liver and other viscera
A50.7 Late congenital syphilis, unspecified
A51.39 Other secondary syphilis of skin
A5...
Screen all people living with HIV and all individuals with high-risk sexual behaviors for syphilis.
Penicillin is the treatment of choice for syphilis.
Syphilis rates are rising—prevalen...
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Pathogenesis of gonococcal infections. Neisseria gonorrhoea is a gram-negative diplococcus whose surface pili form a barrier against phagocytosis by neutrophils. The pili contain an IgA protease that digests IgA on the luminal surface of the mucous membranes of the urethra, endocervix, and fallopian tube, thereby facilitating attachment of gonococci. Gonococci cause endocervicitis, vaginitis, and salpingitis. In men, gonococci attached to the mucous membrane of the urethra cause urethritis ...
Pathogenesis of gonococcal infections. Neisseria gonorrhoea is a gram-negative diplococcus whose surface pili form a barrier against phago...
<bold>FIG. 125.1.</bold> Skin lesions characteristic of septicemia due to <italic>Neisseria gonorrhoeae</bold>. A: Hemorrhagic spot 5 to 6 mm in diameter on the upper arm; the gray area 1 to 2 mm in diameter in the center indicates necrosis. B: Pustulovesicular lesion on the finger of the same patient; the necrotic center is evident as a gray area.
<bold>FIG. 125.1.</bold> Skin lesions characteristic of septicemia due to <italic>Neisseria gonorrhoeae</bold>. A:...
FIG. 11.50. Disseminated gonococcemia. Neisseria gonorrhoeae may disseminate from mucosal surfaces via the bloodstream and produce arthritis/arthralgia and a rash. The most characteristic lesion is the hemorrhagic vesicopustule seen in the web space of the teenage girl's hand. There is a pustule on the sole of her foot.
FIG. 11.50. Disseminated gonococcemia. Neisseria gonorrhoeae may disseminate from mucosal surfaces via the bloodstream and produce arthrit...
Chlamydial mucopurulent cervicitis.
Disseminated gonorrhea: pustule with hemorrhagic base and necrotic center.
Fig. 17-10 Urethral discharge associated with gonorrhea. This discharge may vary in color and copiousness and is accompanied by burning during urination.
Fig. 17-10 Urethral discharge associated with gonorrhea. This discharge may vary in color and copiousness and is accompanied by burning du...
<bold>FIGURE 2-10.</bold> The illusion of depth when using scanning electron microscopy clearly reveals the corkscrew shape of cells of the syphilis-causing spirochete, <italic>Treponema pallidum</bold>.
<bold>FIGURE 2-10.</bold> The illusion of depth when using scanning electron microscopy clearly reveals the corkscrew shape of ...
<bold><italic>Figure 20-19</bold> Syphilitic aortitis in tertiary syphilis. A,</bold> The aortic root is dilated, so that the valve does not seal properly during diastole (regurgitation), and the valve leaflets are thickened because of chronic inflammation and scarring. <bold>B,</bold> Marked left ventricular dilation and hypertrophy caused by aortic regurgitation associated with dilation of aortic root.
<bold><italic>Figure 20-19</bold> Syphilitic aortitis in tertiary syphilis. A,</bold> The aortic root is dilated, s...
Secondary syphilis. Note the “moth-eaten” appearance of alopecia in this patient. From Goodheart HP. Goodheart's Photoguide to Common Skin Disorders: Diagnosis and Management, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins, 2009.
Secondary syphilis. Note the “moth-eaten” appearance of alopecia in this patient. From Goodheart HP. Goodheart's Photoguide to Common Skin ...