A cause of critical limb ischemia
Nonatherosclerotic vasculitis of small- and medium-sized arteries and veins resulting in segmental occlusion of the distal extremity vasculature; cau...
Point scoring systems are available to clarify clinical diagnosis. Two are most referenced:
Shionoya criteria:
Smoking history
Onset <50 years of age
Infrapopliteal arterial occlusions
Either ...
Tobacco cessation (mandatory)
Eliminate other vasoconstrictive triggers (cold/drugs).
Eliminate exposure to chemical damage (e.g., iodine, carbolic acid, salicylic acid).
Avoid ...
Avoid pr...
Abeles AM, Nicolescu M, Pinchover Z, et al. Thromboangiitis obliterans successfully treated with phosphodiesterase type 5 inhibitors. Vascular. 2...
52403007 Thromboangiitis obliterans (disorder)
230601003 Neuropathy in thromboangiitis obliterans (disorder)
Tobacco cessation is mandatory in patients with TAO. Tobacco cessation decreases the risk of amputation. Nicotine replacement therapy may sustain disease activity.
Urinary nicotine and ...
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Buerger disease. The hand shows necrosis of the tips of the fingers.
Vasculitis with petechiae and purpura of lower extremity
<bold><italic>Figure 12-13</bold> Acute necrotizing vasculitis.</bold> This specimen is from a testicular biopsy in a patient with polyarteritis nodosa. The biopsy was performed to confirm a provisional clinical diagnosis.
<bold><italic>Figure 12-13</bold> Acute necrotizing vasculitis.</bold> This specimen is from a testicular biopsy i...
close up of previous patient's lower extremity
Buerger disease. (A) Section of the upper extremity shows an organized arterial thrombus, which has occluded the lumen. Some inflammatory cells are evident in the adventitial fat. In this instance, the vein (arrow) and the adjacent nerve (arrowhead) show foci of chronic inflammation.
Buerger disease. (A) Section of the upper extremity shows an organized arterial thrombus, which has occluded the lumen. Some inflammatory c...