An acute syndrome of microangiopathic hemolytic anemia (MAHA) and consumptive thrombocytopenia with deposition of hyaline thrombi in terminal arterioles and capillaries leading to is...
Screening ADAMTS13 activity level
<10% defines severe deficiency, and makes TTP more likely. Levels of 10-20% suggest possible TTP especially if drawn after PEX has been initiate...
Prompt treatment of presumptive or confirmed TTP is necessary due to the high mortality (90%).
Complete response to treatment is defined by a platelet count >150 × 109/L for 2 consecu...
Self-monitor for signs of ...
M31.1 Thrombotic microangiopathy
D69.42 Congenital and hereditary thrombocytopenia purpura
D69.3 Immune thrombocytopenic purpura
78129009 Thrombotic thrombocytopenic purpura (disorder)
37...
The diagnosis of TTP is made clinically; symptoms are nonspecific: nausea; vomiting; weakness; abdominal pain; fatigue; fever; and easy bruising, purpura, or petechiae.
The pentad of fe...
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<bold>FIGURE 20-28. Thrombotic thrombocytopenic purpura.</bold> Microthrombi are present in the brain <bold>(A)</bold> and heart <bold>(B)</bold> of a patient who died of thrombotic thrombocytopenic purpura.
<bold>FIGURE 20-28. Thrombotic thrombocytopenic purpura.</bold> Microthrombi are present in the brain <bold>(A)</bold...
<bold>FIGURE 20-29. Microangiopathic hemolytic anemia.</bold> Numerous schistocytes (arrows) are present in a patient with thrombotic thrombocytopenic purpura.
<bold>FIGURE 20-29. Microangiopathic hemolytic anemia.</bold> Numerous schistocytes (arrows) are present in a patient with thr...
Buerger disease. (A) Section of the upper extremity shows an organized arterial thrombus, which has occluded the lumen. Some inflammatory cells are evident in the adventitial fat. In this instance, the vein (arrow) and the adjacent nerve (arrowhead) show foci of chronic inflammation.
Buerger disease. (A) Section of the upper extremity shows an organized arterial thrombus, which has occluded the lumen. Some inflammatory c...