Onset is typically 1 to 3 weeks after initiation of drug.
Prodrome of fever, malaise, headache, sore throat, and conjunctivitis followed by skin lesions after 1 to 3 days (detailed bel...
Supportive care is still the mainstay of TEN treatment; withdrawal of offending drug agent, if known, is imperative.
Early transfer to an ICU/burn unit is critical, as patients can rapidly de...
Avoidance of inciting drug or drug class in the future
Monitoring of dermatologic and ocular sequelae
Skin reepithelialization usually occurs within 1 to 3...
Valeyrie-Allanore L, Bastuji-Garin S, Guégan S, et al. Prognostic value of histologic features of toxic epidermal necrolysis. J Am Acad Dermatol. 2013;68(2):e29–e35.
Vélez NF, ...
23067006 Lyell's toxic epidermal necrolysis, subepidermal type (disorder)
402744003 toxic epidermal necro...
SJS and TEN are on a spectrum, with TEN the more severe disease.
Expert care in burn centers improves outcomes.
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