Onset is typically 1 to 3 weeks after initiation of drug.
Prodrome of fever, malaise, headache, sore throat, and conjunctivitis followed by skin lesions after 1 to 3 days (detailed bel...
Most important medical management requires 1) early recognition of diagnosis, 2) withdrawl of offending drug agent, and 3) supportive care.
Early transfer to an ICU/burn unit is critical beca...
Avoidance of inciting drug or drug class in the future
Monitoring of dermatologic and ocular sequelae
Skin reepithelialization usually occurs within 1 to 3...
Abe R. Immunological response in Stevens-Johnson syndrome and toxic epidermal necrolysis. J Dermatol. 2015;42(1):42–48. [View Abstract on OvidMedli...
23067006 Lyell’s toxic epidermal necrolysis, subepidermal type (disorder)
402744003 toxic epidermal necrolysis due to drug (disorder)
403214005 ...
SJS and TEN are on a spectrum, with TEN the more severe disease.
Expert care in burn centers improves outcomes.
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