Toxoplasma gondii is an obligate intracellular protozoan parasite.
Most common latent protozoan infection
Clinically significant disease typically manifests only in pregnancy or in an immunocompr...
Congenital toxoplasmosis
Clinical presentation varies widely; 80% of patients are asymptomatic at birth.
Classic triad (uncommon): chorioretinitis, hydrocephalus, cerebral calcification...
Important: All pyrimethamine-containing regimens should include leucovorin (folinic acid 10 to...
Monitor for bone marrow, renal, or liver toxicity.
Good hydration: Sulfadiazine is poorly soluble and may crystallize in the urine.
Wa...
B58.9 Toxoplasmosis, unspecified
P37.1 Congenital toxoplasmosis
B58.2 Toxoplasma meningoencephalitis
B58.00 Toxoplasma oculopathy, unspecified
187192000 Toxoplasmosis (disorder)
73893000 C...
Toxoplasmosis is typically asymptomatic in immunocompetent patients.
Primary prevention is important, particularly for pregnant women and immunodeficient patients.
The most common manife...
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<bold>Figure 48-6</bold> Active chorioretinitis in a 5-month-old boy with untreated congenital toxoplasmosis.
Figure 173.2. Life cycle and modes of transmission of <italic>Toxoplasma gondii</bold>. Infection in humans and other animals occurs primarily after ingestion of either the cyst or the oocyst. Released organisms invade the intestinal epithelium, spread to tissues (either hematogenously or through lymphatics), and form cysts. When humans or other animals (including the cat) eat infected tissues (from any animal) or mature oocysts (excreted only by members of the cat family), the life cycle is comple...
Figure 173.2. Life cycle and modes of transmission of <italic>Toxoplasma gondii</bold>. Infection in humans and other animals ...