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Transfusion Reaction, Hemolytic

Federico Delgado, MD and Gabriel M. Aisenberg, MD Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Every year, >5 million people in the United States receive a transfusion.

  • Although it provides benefits, transfusion of blood products can result in a variety of serious complicati...

DIAGNOSIS

ALERT
  • Symptoms are masked in the anesthetized patient; among this population, the first sign of hemolytic reaction may be red-tinged urine in the catheter.

  • Shortness of breath, high fever, los...

TREATMENT

GENERAL MEASURES

  • Follow hospital protocol for evaluation of transfusion reactions.

  • Stop transfusion immediately if hemolytic transfusion reaction is suspected.

  • Ensure IV line patent.

  • IV normal s...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

Until hemolytic signs are gone 

DIET

As tolerated 

PATIENT EDUCATION

Before starting a transfusion, give the patient instructions to report any unus...

REFERENCES

1
Bryan S. Hemolytic transfusion reaction: safeguards for practice. J Perianesth Nurs.  2002;17(6):399–403. [View Abstract on OvidMedline]

ADDITIONAL READING

  • Davenport RD. Pathophysiology of hemolytic transfusion reactions. Semin Hematol.  2005;42(3):165–168. [View Abstract on OvidMedline]

  • Davenport RD. The role of cytokines in hemol...

CODES

ICD10

  • T80.919A Hemolytic transfusion reaction, unspecified incompatibility, unspecified as acute or delayed, initial encounter

  • T80.910A Acute hemolytic transfusion reaction, unspecified incompatib...

CLINICAL PEARLS

  • Transfusion of packed RBCs depresses the immune response in patients undergoing renal transplantation.

  • In an anesthetized patient, increased bleeding, oozing from catheter sites, and re...

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