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Tuberculosis, Latent (LTBI)

Kay A. Bauman, MD, MPH Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Latent tuberculosis infection (LTBI) is an asymptomatic, noninfectious condition following exposure to an active case of tuberculosis. LTBI is usually detected by a positive skin tes...

DIAGNOSIS

HISTORY

Assess risk; history of immigration from a high-risk area including those with temporary visas for school or work (note: TB screening for this type of visa is not required, unlike reg...

TREATMENT

GENERAL MEASURES

  • Must exclude active TB

  • Treatment for LTBI is critical for the control and elimination of TB disease. LTBI treatment decreases the risk of active TB and decreases risk of poten...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • During preventive therapy for LTBI: monthly visits to assess adherence and monitor for hepatitis and neuropathy; if stable, can monitor less fre...

REFERENCES

1
Stewart R, Tsang C, Pratt R, et al. Tuberculosis—United States, 2017. MMWR Morb Mortal Wkly Rep.  2018;67(11):317–323. [View Abstract on OvidMedline]
2
Weinberg M, Cherry C, Lipnitz J, ...

ADDITIONAL READING

Centers for Disease Control and Prevention. Latent tuberculosis infection: a guide for primary health care providers. http://www.cdc.gov/tb/publications/ltbi/treatment.htm. Accessed...

CODES

ICD10

R76.11 Nonspecific reaction to skin test w/o active tuberculosis 

ICD9

795.51 Nonspecific reaction to tuberculin skin test without active tuberculosis 

SNOMED

11999007 inactive tuberculosis (di...

CLINICAL PEARLS

  • ~4% of the U.S. population has LTBI.

  • Treatment of LTBI is crucial to the control and elimination of TB disease in the United States.

  • Screen foreign-born persons for latent TB, and treat ...

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