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Tuberculosis, Latent (LTBI)

Kay A. Bauman, MD, MPH Reviewed 06/2018
 


BASICS

DESCRIPTION

  • Latent tuberculosis infection (LTBI) is an asymptomatic, noninfectious condition following exposure to an active case of tuberculosis. LTBI is usually detected by a positive skin tes...

DIAGNOSIS

HISTORY

Assess risk. History of immigration from a high-risk area including those with temporary visas for school or work (Note: TB screening for this type of visa is not required, unlike reg...

TREATMENT

GENERAL MEASURES

  • Must exclude active TB

  • Treatment for LTBI is critical for the control and elimination of TB disease. LTBI treatment decreases the risk of active TB and decreases risk of poten...

ONGOING CARE

FOLLOW UP RECOMMENDATIONS

Patient Monitoring

  • During preventive therapy for LTBI: monthly visits to assess adherence and monitor for hepatitis and neuropathy; if stable, can monitor less fre...

REFERENCES

1
Schmit K, Wansaula Z, Pratt R, et al. Tuberculosis—United States, 2016. MMWR Morb Mortal Wkly Rep.  2017;66(11):289–294. [View Abstract on OvidMedline]
2
Weinberg M, Cherry C, Lipnitz ...

ADDITIONAL READING

SEE ALSO

Tuberculosis; Tuberculosis, Miliary 

CODES

ICD10

R76.11 Nonspecific reaction to skin test w/o active tuberculosis 

ICD9

795.51 Nonspecific reaction to tuberculin skin test without active tuberculosis 

SNOMED

11999007 inactive tuberculosis (di...

CLINICAL PEARLS

  • ~4% of the U.S. population has LTBI.

  • Treatment of LTBI is crucial to the control and elimination of TB disease in the United States.

  • Screen foreign-born persons for latent TB, and treat ...

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