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von Willebrand Disease

Ashten Ray Duncan, MD, MPH, CPH Reviewed 04/2024
 


BASICS

DESCRIPTION

  • von Willebrand disease (vWD) is a lifelong bleeding disorder resulting from either a quantitative or qualitative (e.g., structural or functional) defect in von Willebrand factor (vWF...

DIAGNOSIS

  • Accurate diagnosis of vWD requires taking into account both personal and family history of bleeding and lab results showing abnormalities in vWF and/or FVIII.

  • For patients with low probabilit...

TREATMENT

GENERAL MEASURES

  • Minor bleeding episodes generally do not require therapeutic intervention. Most commonly, these individuals receive treatment prior to undergoing surgeries, dental procedures...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patients should be seen by a hematologist prior to invasive procedures to reduce risk of excessive bleeding. 

Patient Monitoring

  • Repeat laboratory studies can be co...

REFERENCES

1
Du P, Bergamasco A, Moride Y, et al. Von Willebrand Disease Epidemiology, Burden of Illness and Management: A Systematic Review. J Blood Med. 2023;14:189-208.

SEE ALSO

Algorithms: Bleeding Gums; Ecchymosis 

DES

ICD10

  • D68.0 Von Willebrand's disease

SNOMED

  • 234451005 Acquired von Willebrand's disease

  • 359725000 Hereditary von Willebrand disease type 2M

  • 359732009 von Willebrand disease type 2N

  • 359711001 Hereditary ...

CLINICAL PEARLS

  • vWD is the most common inherited bleeding disorder in American adults, and its manifestations vary from minor to severe bleeding episodes.

  • Clinicians should be highly suspicious of vWD ...

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