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von Willebrand Disease

Brandon A Wilkins, D.O. and Tyler D Sharpe, MD Reviewed 05/2023
 


BASICS

DESCRIPTION

  • von Willebrand disease (vWD) is a lifelong bleeding disorder resulting from either a quantitative or qualitative defect in von Willebrand factor (vWF) protein.

  • vWF plays an essential ...

DIAGNOSIS

  • Diagnosing vWD requires taking into account both personal and family history of bleeding and lab results showing abnormalities in vWF and/or Factor VIII.

  • For patients with low probability of ...

TREATMENT

GENERAL MEASURES

  • Minor bleeding episodes generally do not require therapeutic intervention. Most commonly, these individuals receive treatment prior to receiving surgeries, dental procedures,...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patients should be seen by a hematologist prior to invasive procedures. 

Patient Monitoring

Patients with mild disease do not require monitoring. 

DIET

No dietary res...

REFERENCES

1
Leebeek FW, Eikenboom JC. Von Willebrand's Disease. N Engl J Med. 2016;375(21):2067-2080. 
2
Baronciani L, Peyvandi F. How we make an accurate diagnosis of von Willebrand disease. Thromb Res...

SEE ALSO

Algorithms: Bleeding Gums; Ecchymosis 

CODES

ICD10

  • D68.0 Von Willebrand's disease

SNOMED

  • 234451005 Acquired von Willebrand's disease

  • 359725000 Hereditary von Willebrand disease type 2M

  • 359732009 von Willebrand disease type 2N

  • 359711001 Hereditar...

CLINICAL PEARLS

  • vWD is the most common inherited bleeding disorder in American women, and its manifestations vary from minor to severe bleeding episodes.

  • Treatment should be administered for recurrent ...

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