A disease characterized by granulomatous vasculitis involving multiple organs
The characteristic triad of involvement includes the upper airway (e.g., otitis, sinusitis, nasal mucosa)...
Fever: 34%
Weight loss: 16%
Cough: 34%
Arthralgia/arthritis: 44%
Epistaxis: 11%
Hemoptysis: 18%
Rash: 13%
Chest pain, anorexia, proptosis, dyspnea, oral ulcers, hearing loss, headache: all ...
Patients with significant renal involvement or serious pulmonary disease require cyclophosphamide or rituximab for optimal initial control in most cases but may be converted to methotrexate,...
BP, glucose, and potassium for steroid effects
CBC with differential every 1 to 2 weeks to monitor for bone marrow toxicity from cyclophosphamide...
M31.30 Wegener's granulomatosis without renal involvement
M31.31 Wegener's granulomatosis with renal involvement
195353004 Wegener's granulomatosis (disorder)
232460001 Wegener's granulo...
Biopsies of mucosal lesions, skin lesions, lung, or kidney typically are needed to confirm a diagnosis of Wegner granulomatosis, but tissue diagnosis is often difficult unless an open ...
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<bold>FIG. 83.11.</bold> Cutaneous findings in ANCA-associated vasculitides. A: Purpura in microscopic polyangiitis. B: Splinter hemorrhages in Wegener's granulomatosis.
<bold>FIG. 83.11.</bold> Cutaneous findings in ANCA-associated vasculitides. A: Purpura in microscopic polyangiitis. B: Splinte...