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Wilms Tumor

Chad Hamner, MD Reviewed 06/2020
 


BASICS

DESCRIPTION

  • Most common renal tumor in children; fifth most common pediatric malignancy

  • An embryonal renal neoplasm containing blastemal, stromal, or epithelial cell types, usually affecting chil...

DIAGNOSIS

HISTORY

  • >90% present with asymptomatic abdominal mass

  • Most common symptoms and signs: abdomen pain (40%), hypertension (25%), gross hematuria (18%)

  • Associated symptoms (10%): fever, weight l...

TREATMENT

GENERAL MEASURES

  • All patients with Wilms tumor should be considered for entry into available clinical trials.

  • Treatment combines surgical resection, postoperative with or without neoadjuvant c...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Multidrug chemotherapy every 3 to 4 weeks for 16 weeks to 15 months depending on stage, then every 4 months for 1 year, every 6 months for 2nd t...

REFERENCES

1
National Cancer Institute. (2012–2019). Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ): Health Professional Version. Retrieved from https://www.cancer.gov/types/kidney/hp/wi...

CODES

ICD10

  • C64.9 Malignant neoplasm of unsp kidney, except renal pelvis

  • C64.1 Malignant neoplasm of right kidney, except renal pelvis

  • C64.2 Malignant neoplasm of left kidney, except renal pelvis

ICD9

189....

CLINICAL PEARLS

  • Wilms is the most common renal tumor in children; usually affecting children <5 years of age.

  • Overall survival ranges from 30–100% with worse outcomes associated with anaplasia, adva...

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