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Wilms Tumor

John K. Uffman, MD, MPH Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Most common renal tumor in children; fifth most common pediatric malignancy

  • An embryonal renal neoplasm containing blastemal, stromal, or epithelial cell types, usually affecting chil...

DIAGNOSIS

  • Symptoms of pain, anorexia, vomiting, malaise in 30% (1)

  • >90% present with asymptomatic abdominal mass (2)

HISTORY

  • History of increasing abdominal size

  • Usually asymptomatic; may have fever, a...

TREATMENT

GENERAL MEASURES

  • Appropriate health care: inpatient workup and treatment until stable postoperatively and induction chemotherapy completed

  • Chemotherapy; some recommend pretreatment with neoadj...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Patient Monitoring

  • Multidrug chemotherapy every 3 to 4 weeks for 16 weeks to 15 months depending on stage

  • Every 4 months for 1 year, every 6 months for 2nd to 3rd y...

REFERENCES

1
Sonn G, Shortliffe LM. Management of Wilms tumor: current standard of care. Nat Clin Pract Urol.  2008;5(10):551–560. [View Abstract on OvidMedline]
2
Davidoff AM. Wilms tumor. Adv Pedi...

CODES

ICD10

  • C64.9 Malignant neoplasm of unsp kidney, except renal pelvis

  • C64.1 Malignant neoplasm of right kidney, except renal pelvis

  • C64.2 Malignant neoplasm of left kidney, except renal pelvis

ICD9

189....

CLINICAL PEARLS

  • Wilms is the most common renal tumor in children; it is an embryonal renal neoplasm containing blastemal, stromal, or epithelial cell types, usually affecting children <5 years of a...

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