Zollinger-Ellison syndrome (ZES) triad
Markedly elevated gastric acid secretion
Peptic ulcer disease
A gastrinoma or non-β islet cell tumor of the pancreas or duodenal wall that produce...
Abdominal pain is the most common symptom (80%).
Diarrhea (postprandial and fasting) (70%)
Heartburn...
Goals are to control acid hypersecretion and resect the tumor.
Advanced imaging initially to evaluate for resection
Surgical removal when primary tumor can be identified and as...
Longitudinal follow-up to evaluate for metastases. Reoperation may be considered (4).
Titrate medical therapy to control symptoms.
Advise patient...
De Angelis C, Corgegoso-Valdivia P, Venezia L, et al. Diagnosis and management of Zollinger-Ellison syndrome in 2018. Minerva Endocrinol. 2018;43(2):212-220. ...
Consider Zollinger-Ellison syndrome if peptic ulcers recur or if unusually high doses of PPI are needed to control symptoms.
Abdominal pain and diarrhea should be totally controllable w...
Sign up for a 10-day FREE Trial now and receive full access to all content.