Zollinger-Ellison Syndrome

Zollinger-Ellison syndrome (ZES) triad

• Markedly elevated gastric acid secretion

• Peptic ulcer disease

• A gastrinoma or non-β islet cell tumor of the pancreas or duodenal wall that produce...

Abdominal pain is the most common symptom (80%).

Diarrhea (postprandial and fasting) (70%)

Heartburn...

Goals are to control acid hypersecretion and resect the tumor.

Advanced imaging initially to evaluate for resection

Surgical removal when primary tumor can be identified and as...

Longitudinal follow-up to evaluate for metastases. Reoperation may be considered .

Titrate medical therapy to control symptoms.

Advise patients of...

Consider Zollinger-Ellison syndrome if peptic ulcers recur or if unusually high doses of PPI are needed to control symptoms.

Abdominal pain and diarrhea should be totally controllable w...