Zollinger-Ellison syndrome (ZES) triad
Markedly elevated gastric acid secretion
Peptic ulcer disease
A gastrinoma or non-β islet cell tumor of the pancreas or duodenal wall that produce...
Abdominal pain is the most common symptom (80%).
Diarrhea (postprandial and fasting) (70%)
Heartburn...
Goals are to control acid hypersecretion and resect the tumor.
Advanced imaging initially to evaluate for resection
Surgical removal when primary tumor can be identified and as...
Longitudinal follow-up to evaluate for metastases. Reoperation may be considered (4).
Titrate medical therapy to control symptoms.
Advise patients...
De Angelis C, Cortegoso Valdivia P, Venezia L, et al. Diagnosis and management of Zollinger-Ellison syndrome in 2018. Minerva Endocrinol. 2018;43(2):212–220.
Smallfield GB, All...
Consider Zollinger-Ellison syndrome if peptic ulcers recur or if unusually high doses of PPI are needed to control symptoms.
Abdominal pain and diarrhea should be totally controllable w...
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