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Acute Lymphoblastic Leukemia, Pediatric

Monica Zlotnicki, MD and Caroline Hastings, MD Reviewed 10/2018
 


BASICS

DESCRIPTION

  • Acute lymphoblastic leukemia (ALL) is a hematopoietic malignancy that results from malignant proliferation of immature WBC (B cells and T cells).

  • Risk group classification:

    • Infant ALL:...

DIAGNOSIS

  • Clinical features due to direct invasion of the bone marrow:

    • Pancytopenia: anemia, thrombocytopenia, leukopenia, and/or neutropenia

    • Anemia: irritability, fatigue, anorexia, headache, pallor

    • Thr...

TREATMENT

  • Patient suspected with ALL must be referred to a pediatric oncologist as soon as possible for further evaluation and management.

  • Initial emergent stabilization may be required in case of

    • Hyper...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Early intensification has led to an increase in relapse-free survival. 

Patient Monitoring

After completion of therapy: 
  • CBC, complete metabolic panel with LDH, live...

ADDITIONAL READING

  • Cooper SL, Brown PA. Treatment of pediatric acute lymphoblastic leukemia. Pediatr Clin North Am.  2015;62(1):61–73. [View Abstract on OvidInsights]

  • Hunger SP, Loh ML, Whitlock J...

CODES

ICD9

  • 204 Acute lymphoid leukemia without mention of having achieved remission

  • 204.01 Acute lymphoid leukemia, in remission

  • 204.02 Acute lymphoid leukemia, in relapse

ICD10

  • C91.00 Acute lymphoblastic ...

FAQ

  • Q: Can a child on treatment for ALL go to school or leave the house?

  • A: Yes. Most centers encourage the child to live a normal life, including school, activities, and travel.

  • Q: Will hair fall out a...

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