Autoimmune hemolytic anemia (AIHA) is characterized by shortened red cell survival caused by autoantibodies directed against RBC surface antigens, with or without the participation o...
Pallor
Jaundice
Dark urine
Fever
Weakness
Dizziness
Syncope
Exercise intolerance
Splenomegaly
Hepatomegaly
Tachycardia, systolic flow murmur, S3 gallop
Orthostasis in ...
Corticosteroids
Indication:
In IgG-mediated disease, steroids have been shown to interfere with macrophage Fc and C3b receptors responsible for RBC destruction. In addition...
Hemoglobin level q4h–q12h (depending on severity) until stable
Reticulocyte count: daily
Spleen size: daily
Hemoglobinuria: daily
Coombs: weekly
Barros MMO, Blajchman MA, Bordin JO. Warm autoimmune hemolytic anemia: recent progress in understanding the immunobiology and treatment. Transfus Med Rev. 2010;24(3):195–210. ...
283.0 Autoimmune hemolytic anemias
D59.1 Other autoimmune hemolytic anemias
D59.0 Drug-induced autoimmune hemolytic anemia
413603009 Autoimmune hemolytic anemia (disorder)
309742004 D...
Q: Will the anemia go away?
A: Children with cold autoantibodies tend to have short-lived illness, whereas children with warm antibodies often have a chronic clinical course characterized by period...
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FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population. A distinct population of hypochromic, often microcytic erythrocytes can be found admixed with normochromic, normocytic, or macrocytic erythrocytes.
FIGURE 41.7. The peripheral blood smear of refractory anemia with ringed sideroblasts is characterized by a dimorphic red cell population....
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decreased Microcytic, hypochromic anemia Reticulocytes normal or slightly increased Increased RDW Pencil or cigar shaped red cells, codocytes Bone marrow Normoblastic hyperplasia Absent hemosiderin Decreased sideroblasts (less than 10%) Normoblasts are smaller than normal with ragged rims of cytoplasm containing little h...
Iron Deficiency Anemia (IDA) White cells Not remarkable Platelets Normal or slightly increased Red cells Hb and Hct decrease...
Immune Hemolytic Anemia White cells May be elevated due to an increased in neutrophils Counts may approach 30 X 10<sup>9</sup> /L Platelets Usually normal Red cells Hb and Hct decreased Normocytic, normochromic anemia Reticulocytes increased Increased MCV is due to prominent reticulocytosis Spherocytes Bone marrow Hypercellular with erythroid precursors Peripheral Smear
Immune Hemolytic Anemia White cells May be elevated due to an increased in neutrophils Counts may approach 30 X 10<sup>9</...
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia Increased reticulocytes Schistocytes Polychromatophilia Peripheral Smear
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia ...