Increasing incidence worldwide
Due to stricter newborn screening thresholds, changing demographics
Overall incidence: about 1 in 2,...
Newborn screening results (including hearing test)
Maternal use of antithyroid drugs
Maternal iodine ingestion (e.g., iodine supplements, seaweed)
Family history of thyroid ...
Start treatment immediately if
Newborn screen TSH ≥40 mIU/L (draw confirmatory serum tests and start treatment while awaiting results)
Serum TSH ≥20 mIU/L
Serum TSH and free T4 should be measured.
Every 1 to 2 weeks until TSH and free T4 are normal
Every 1 to 3 months until 12 months of age
Every 2 to...
LaFranchi SH. Approach to the diagnosis and treatment of neonatal hypothyroidism. J Clin Endocrinol Metab. 2011;96(10):2959–2967. [View Abstract on OvidInsights]
Léger J, Olivi...
E03.1 Congenital hypothyroidism without goiter
E03.0 Congenital hypothyroidism with diffuse goiter
190268003 Congenital hypothyroidism (disorder)
Q: What causes congenital hypothyroidism?
A: Most cases are caused by failure of the thyroid gland to form correctly (dysgenesis). Almost all of these cases are sporadic, and the underlying cause i...
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