Hypothyroidism, Congenital, Pediatric

Increasing incidence worldwide

• Due to stricter newborn screening thresholds, changing demographics

• Overall incidence: about 1 in 2,...

Birth history

Newborn screening results (including hearing test)

Maternal use of antithyroid drugs

Maternal iodine ingestion (e.g., iodine supplements, seaweed)

Family history of thyroid ...

Start treatment immediately if

• Newborn screen TSH ≥40 mIU/L (draw confirmatory serum tests and start treatment while awaiting results)

• Serum TSH ≥20 mIU/L

• Serum TS...

Serum TSH and free T₄ should be measured.

• Every 1 to 2 weeks until TSH and free T₄ are normal

• Every 1 to 3 months until 12 months of age

• Every 2 to...

LaFranchi SH. Approach to the diagnosis and treatment of neonatal hypothyroidism. J Clin Endocrinol Metab.  2011;96(10):2959–2967. [View Abstract on OvidInsights]

Léger J, Olivi...

E03.1 Congenital hypothyroidism without goiter

E03.0 Congenital hypothyroidism with diffuse goiter

190268003 Congenital hypothyroidism (disorder)

278503...

Q: What causes congenital hypothyroidism?

A: Most cases are caused by failure of the thyroid gland to form correctly (dysgenesis). Almost all of these cases are sporadic, and the underlying cause i...