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Cytomegalovirus Infections, Pediatric

Michelle Marie Gontasz, MD and Ravit Arav-Boger, MD Reviewed 10/2018
 


BASICS

DESCRIPTION

Cytomegalovirus (CMV) is a ubiquitous double-stranded DNA virus that is a member of the herpesvirus family. It establishes latency in peripheral blood mononuclear cells and endotheli...

DIAGNOSIS

HISTORY

  • Relevant exposures include

    • Day care attendance; increased risk of infection

    • Recent blood transfusion; risk of transfusion-associated CMV

    • Use of immunosuppressive medications; associated ...

TREATMENT

Majority of transplant experts prefer prophylaxis over preemptive therapy in high-risk patients (donor CMV positive, recipient negative). 

MEDICATION

First Line

ONGOING CARE

PROGNOSIS

Varies with nature of infection (see “Commonly Associated Conditions“) 

COMPLICATIONS

Varies with nature of infection (see “Commonly Associated Conditions“) 

ADDITIONAL READING

  • Alexander BT, Hladnik LM, Augustin KM, et al. Use of cytomegalovirus intravenous immune globulin for the adjunctive treatment of cytomegalovirus in hematopoietic stem cell transplan...

CODES

ICD9

  • 78.5 Cytomegaloviral disease

  • 771.1 Congenital cytomegalovirus infection

ICD10

  • B25.9 Cytomegaloviral disease, unspecified

  • P35.1 Congenital cytomegalovirus infection

  • B25.0 Cytomegaloviral pneumonit...

FAQ

  • Q: Should children with congenital CMV infection be excluded from day care settings?

  • A: No. Due to the high frequency of shedding of CMV in the urine and saliva of asymptomatic children, especially...

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