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Cytomegalovirus Infections, Pediatric

Michelle Marie Gontasz, MD and Ravit Arav-Boger, MD Reviewed 10/2018
 


BASICS

DESCRIPTION

Cytomegalovirus (CMV) is a ubiquitous double-stranded DNA virus that is a member of the herpesvirus family. It establishes latency in peripheral blood mononuclear cells and endotheli...

DIAGNOSIS

HISTORY

  • Relevant exposures include

    • Day care attendance; increased risk of infection

    • Recent blood transfusion; risk of transfusion-associated CMV

    • Use of immunosuppressive medications; associated ...

TREATMENT

Majority of transplant experts prefer prophylaxis over preemptive therapy in high-risk patients (donor CMV positive, recipient negative). 

MEDICATION

First Line

  • Ganciclovir: suppresses viral re...

ONGOING CARE

PROGNOSIS

Varies with nature of infection (see “Commonly Associated Conditions“) 

COMPLICATIONS

Varies with nature of infection (see “Commonly Associated Conditions“) 

ADDITIONAL READING

  • Alexander BT, Hladnik LM, Augustin KM, et al. Use of cytomegalovirus intravenous immune globulin for the adjunctive treatment of cytomegalovirus in hematopoietic stem cell transplan...

CODES

ICD9

  • 78.5 Cytomegaloviral disease

  • 771.1 Congenital cytomegalovirus infection

ICD10

  • B25.9 Cytomegaloviral disease, unspecified

  • P35.1 Congenital cytomegalovirus infection

  • B25.0 Cytomegaloviral pneumonit...

FAQ

  • Q: Should children with congenital CMV infection be excluded from day care settings?

  • A: No. Due to the high frequency of shedding of CMV in the urine and saliva of asymptomatic children, especially...

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