Early aggressive therapy improves overall outcome and reduces frequency of calcinosis.
Prednisone 1 to 2 mg/kg/24 h PO (maximum 60 mg) for 1 month, taper over months to years
IV meth...
Serial evaluation of muscle strength and function using validated measures such as the Childhood Myositis Assessment Scale or Manual Muscle Test...
Feldman BM, Rider LG, Reed AM, et al. Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood. Lancet. 2008;371(9631): 2201–2212. [View Abstract on ...
710.3 Dermatomyositis
710.4 Polymyositis
M33.00 Juvenile dermatopolymyositis, organ involvement unspecified
M33.02 Juvenile dermatopolymyositis with myopathy
1212005 Childhood type de...
Q: Is it mandatory to perform a muscle biopsy to confirm the diagnosis?
A: Biopsy is indicated if diagnosis is in any way uncertain. In patients with classic rash, weakness, and elevated muscle enz...
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<bold>FIG. 75.3.</bold> Histopathology of inflammatory myopathies. A,B: Muscle biopsies from polymyositis patients tend to show focal endomysial infiltration by mononuclear cells (A: hematoxylin and eosin stain), while those from dermatomyositis patients show more perivascular and interstitial inflammation with perifascicular myofiber atrophy (B: modified trichrome stain). C: Transverse fresh-frozen section of muscle from a patient with inclusion body myositis displaying purplish granular materia...
<bold>FIG. 75.3.</bold> Histopathology of inflammatory myopathies. A,B: Muscle biopsies from polymyositis patients tend to sho...
<bold>FIG. 75.1.</bold> Skin changes seen in dermatomyositis. A: Gottron's papules are scaly papules overlying the extensor surfaces of the hands (over the metacarpophalangeal and proximal interphalangeal joints in this case), elbows, knees, or malleoli. This patient also has sclerodactyly and arthritis of the metacarpophalangeal and proximal interphalangeal joints. B: The heliotrope rash is a purplish discoloration around the eyes, especially on the upper lids. C: Linear extensor erythema overli...
<bold>FIG. 75.1.</bold> Skin changes seen in dermatomyositis. A: Gottron's papules are scaly papules overlying the extensor sur...
FIG. 2.18. This patient with dermatomyositis has the characteristic facial (A) and extremity findings (B).
<bold><italic>Figure 7.31.</bold></bold> Classic heliotropic rash about the eyes of this patient with dermatomyositis.
<bold><italic>Figure 7.31.</bold></bold> Classic heliotropic rash about the eyes of this patient with dermatomyosit...
Dermatomyositis: face
Dermatomyositis: nail-fold dilated capillary loops