Worldwide d...
A prodrome may occur.
Most often, lasts 3 to 5 days
Malaise, fatigue, with or without fever
In the acute phase, the following features are common:
Fever: begins abruptly, lasts 1 to 2 wee...
Acetaminophen or ibuprofen reduces fever and provides analgesia.
Corticosteroids (prednisone 1 mg/kg/24 h PO, maximum of 20 mg/24 h) may reduce swelling of lymphoid tissues (see “FA...
Immunocompetent individuals usually recover uneventfully in 1 to 4 weeks.
Recovery is often biphasic, with a worsening of symptoms after a period...
Balfour HH Jr, Dunmire SK, Hogquist KA. Infectious mononucleosis. Clin Transl Immunology. 2015;4(2):e33. [View Abstract on OvidInsights]
Bravender T. Epstein-Barr virus, cytome...
B27.90 Infectious mononucleosis, unspecified without complication
B27.99 Infectious mononucleosis, unsp with other complication
B27.91 Infectious mononucleosi...
Q: Is a monospot test sensitive for diagnosing acute infection?
A: Heterophile antibodies can be negative in up to 25% of patients in the 1st week of illness, so other diagnostics such as PCR may b...
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Role of Epstein-Barr virus (EBV) in infectious mononucleosis, nasopharyngeal carcinoma, and Burkitt lymphoma. EBV invades and replicates within the salivary glands or pharyngeal epithelium, and is shed into the saliva and respiratory secretions. In some people, the virus transforms pharyngeal epithelial cells, leading to nasopharyngeal carcinoma. In people who are not immune from childhood exposure, EBV causes infectious mononucleosis. EBV infects B lymphocytes, which undergo polyclonal act...
Role of Epstein-Barr virus (EBV) in infectious mononucleosis, nasopharyngeal carcinoma, and Burkitt lymphoma. EBV invades and replicates w...
<bold>Figure 40.11</bold> Tonsils of an adolescent who has infectious mononucleosis; note the red enlarged tonsils with the thick white covering.
<bold>Figure 40.11</bold> Tonsils of an adolescent who has infectious mononucleosis; note the red enlarged tonsils with the t...
Infectious Mononucleosis White cells Agranulocytosis Proliferation of lymphocytes (12-25 X 10 9 /L) Greater than 20% reactive lymphocytes Immunoblasts may be present Plasmacytoid lymphocytes may be present Red cells May have an autoimmune hemolytic anemia Platelets Normal to decreased Serological tests Paul-Bunnell heterophile antibodies positive Peripheral Smear
Infectious Mononucleosis White cells Agranulocytosis Proliferation of lymphocytes (12-25 X 10 9 /L) Greater than 20% reactive lymp...
infectious mononucleosis
<bold><italic>Figure 11-12</bold> The blood in infectious mononucleosis.</bold> The large "atypical" lymphocyte is characteristic.
<bold><italic>Figure 11-12</bold> The blood in infectious mononucleosis.</bold> The large "atypical" lymphocyte is...
<bold>FIGURE 20-50. Infectious mononucleosis.</bold> Atypical lymphocytes are characteristic.
Eruption occurring in a young man who received amoxicillin just prior to mononucleosis diagnosis
Close-up of previous patient
FIG. 11.55. Pharyngitis in infectious mononucleosis. This girl has inflamed, bilaterally swollen tonsils with a diffuse exudate, as is often seen with infectious mononucleosis.
FIG. 11.55. Pharyngitis in infectious mononucleosis. This girl has inflamed, bilaterally swollen tonsils with a diffuse exudate, as is oft...