Erythema Multiforme, Pediatric

1.70. One month after the acute onset of Stevens-Johnson syndrome, there is still active conjunctival and corneal inflammation and already significant symblepharon formation.

FIG. 2.13. Stevens-Johnson syndrome. A: Adolescent with Stevens-Johnson syndrome secondary to sulfonamides. Note the involvement of mucous membranes of the mouth. B: Same child. Note the distribution of lesions.

FIG. 6.7. Erythema multiforme. Target lesions (A), which consist of a red ring around a clear area (sometimes with a central bull's eye), characterize erythema multiforme. In severe cases (B, C) or with involvement of the mucous membranes (Stevens-Johnson syndrome), vesicles may appear.

<bold>Figure 1-3</bold> Ill-appearing child with Stevens-Johnson syndrome. (Courtesy of Joseph Lopreiato, MD.)

<bold>FIGURE 11.13</bold> (<italic>A</bold>) Toxic epidermal necrolysis (TEN), a severe variant of erythema multiforme major, causes distinct blisters and a characteristic Nikolski sign (arrow) of normal appearing skin sloughing between the bullae. (<italic>B</bold>) Scalded skin with diffuse erythema appears more diffuse and when the skin sloughs, the underlying epidermis is often healed. (<italic>C</bold>) Graft versus host disease can be confused in appearance with TEN, but history of a recent transplant (solid or he...

<bold>FIGURE 11.13</bold> (<italic>A</bold>) Toxic epidermal necrolysis (TEN), a severe variant of erythema multiforme major, causes distinct blisters and a characteristic Nikolski sign (arrow) of normal appearing skin sloughing between the bullae. (<italic>B</bold>) Scalded skin with diffuse erythema appears more diffuse and when the skin sloughs, the underlying epidermis is often healed. (<italic>C</bold>) Graft versus host disease can be confused in appearance with TEN, but history of a recent transplant (solid or he...

<bold>FIGURE 11.13</bold><italic>(continued)</bold> (<italic>A</bold>) Toxic epidermal necrolysis (TEN), a severe variant of erythema multiforme major, causes distinct blisters and a characteristic Nikolski sign (arrow) of normal appearing skin sloughing between the bullae. (<italic>B</bold>) Scalded skin with diffuse erythema appears more diffuse and when the skin sloughs, the underlying epidermis is often healed. (<italic>C</bold>) Graft versus host disease can be confused in appearance with TEN, but history of a recent trans...

toxic epidermal necrolysis

<bold><italic>Figure 14.41.</bold></bold> Erythema multiforme. <bold>A.</bold> Early. <bold>B.</bold> Late.

<bold>Figure 72-8</bold> Hemorrhagic ulcerative stomatitis in SJS. (Courtesy of Joseph Lopreiato, MD.)

<bold>FIGURE 61-20</bold> Erythema-multiforme–like eruption on the patient's arm. Notice the dusky, target-like appearance. (Dermik Laboratories, Inc.) (Sauer G.C., Hall J.C. [1996]. <italic>Manual of skin diseases</bold> [7th ed.]. Philadelphia: Lippincott-Raven)