Erythema multiforme (EM) is an acute, self-limited mucocutaneous eruption characterized by distinct targetoid lesions on the skin.
Although classically defined by the presence of targ...
A prodrome of fever, malaise, and/or symptoms of HSV, Mycoplasma, or other precipitating infections may precede the skin eruption.
Onset is abrupt with rapid evolution of lesions over ...
Treat the underlying cause (e.g., acyclovir for HSV-related cases) or withdraw the offending agent.
EM minor
Care is supportive and symptom-based.
White petrolatum +/− topical c...
The course of EM is self-limited. Lesions resolve in 2 to 4 weeks with postinflammatory pigment alteration. Severe cases of EM may take longer to heal.
Recurrences may occur and a...
Auquier-Dunant A, Mockenhaupt M, Naldi L, et al. Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrol...
695.1 Erythema multiforme, unspecified
695.19 Other erythema multiforme
695.11 Erythema multiforme minor
695.12 Erythema multiforme major
695.13 Stevens-Johnson syndrome
695.14 Stevens-Johnson sy...
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1.70. One month after the acute onset of Stevens-Johnson syndrome, there is still active conjunctival and corneal inflammation and already significant symblepharon formation.
1.70. One month after the acute onset of Stevens-Johnson syndrome, there is still active conjunctival and corneal inflammation and already...
FIG. 2.13. Stevens-Johnson syndrome. A: Adolescent with Stevens-Johnson syndrome secondary to sulfonamides. Note the involvement of mucous membranes of the mouth. B: Same child. Note the distribution of lesions.
FIG. 2.13. Stevens-Johnson syndrome. A: Adolescent with Stevens-Johnson syndrome secondary to sulfonamides. Note the involvement of mucous...
FIG. 6.7. Erythema multiforme. Target lesions (A), which consist of a red ring around a clear area (sometimes with a central bull's eye), characterize erythema multiforme. In severe cases (B, C) or with involvement of the mucous membranes (Stevens-Johnson syndrome), vesicles may appear.
FIG. 6.7. Erythema multiforme. Target lesions (A), which consist of a red ring around a clear area (sometimes with a central bull's eye), ...
<bold>Figure 1-3</bold> Ill-appearing child with Stevens-Johnson syndrome. (Courtesy of Joseph Lopreiato, MD.)
<bold>FIGURE 11.13</bold> (<italic>A</bold>) Toxic epidermal necrolysis (TEN), a severe variant of erythema multiforme major, causes distinct blisters and a characteristic Nikolski sign (arrow) of normal appearing skin sloughing between the bullae. (<italic>B</bold>) Scalded skin with diffuse erythema appears more diffuse and when the skin sloughs, the underlying epidermis is often healed. (<italic>C</bold>) Graft versus host disease can be confused in appearance with TEN, but history of a recent transplant (solid or he...
<bold>FIGURE 11.13</bold> (<italic>A</bold>) Toxic epidermal necrolysis (TEN), a severe variant of erythema multif...
<bold>FIGURE 11.13</bold><italic>(continued)</bold> (<italic>A</bold>) Toxic epidermal necrolysis (TEN), a severe variant of erythema multiforme major, causes distinct blisters and a characteristic Nikolski sign (arrow) of normal appearing skin sloughing between the bullae. (<italic>B</bold>) Scalded skin with diffuse erythema appears more diffuse and when the skin sloughs, the underlying epidermis is often healed. (<italic>C</bold>) Graft versus host disease can be confused in appearance with TEN, but history of a recent trans...
<bold>FIGURE 11.13</bold><italic>(continued)</bold> (<italic>A</bold>) Toxic epidermal necrolysis (TEN...
toxic epidermal necrolysis
<bold><italic>Figure 14.41.</bold></bold> Erythema multiforme. <bold>A.</bold> Early. <bold>B.</bold> Late.
<bold><italic>Figure 14.41.</bold></bold> Erythema multiforme. <bold>A.</bold> Early. <bold>B....
<bold>Figure 72-8</bold> Hemorrhagic ulcerative stomatitis in SJS. (Courtesy of Joseph Lopreiato, MD.)
<bold>FIGURE 61-20</bold> Erythema-multiforme–like eruption on the patient's arm. Notice the dusky, target-like appearance. (Dermik Laboratories, Inc.) (Sauer G.C., Hall J.C. [1996]. <italic>Manual of skin diseases</bold> [7th ed.]. Philadelphia: Lippincott-Raven)
<bold>FIGURE 61-20</bold> Erythema-multiforme–like eruption on the patient's arm. Notice the dusky, target-like appearance. (De...