Pallor, fatigue, and jaundice may occur with either intravascular or extravascular hemolysis.
Hemoglobinuria is a sign of intravascular hemolysis.
General goal is to establish existence...
Avoid triggers of hemolysis (i.e., foods, medications, etc.) for patients with known G6PD deficiency.
Extended cross-match for minor red cell antigens prior to transfusions in...
May need ICU for unstable vital signs
Inpatient care may be required until acute hemolysis slowed or stopped.
Monitor CBC, reticulocyte, LFTs ever...
Gallagher PG. Update on the clinical spectrum and genetics of red blood cell membrane disorders. Curr Hematol Rep. 2004;3(2):85–91. [View Abstract on OvidInsights]
Lo L, Singer...
282.7 Other hemoglobinopathies
283.0 Autoimmune hemolytic anemias
774.0 Perinatal jaundice from hereditary hemolytic anemias
773.1 Hemolytic disease of fetus or newborn due to ABO isoimmunizati...
Q: When are blood transfusions indicated in patients with active hemolysis?
A: Patients with severe, acute hemolysis that is causing cardiovascular compromise may require a transfusion if the proce...
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FIGURE 41.21. Blister cells (A) and bite cells (B) are characteristic of Heinz body-mediated hemolysis. Blister cells appear to have a partially raised or blistered membrane; bite cells appear to have one or more "bites" removed from the cell. Similar bite cells can be found in microangiopathic hemolytic anemia; however, they are then associated with irregular red cell fragments of various sizes and shapes, which are not seen in association with Heinz body-mediated hemolysis.
FIGURE 41.21. Blister cells (A) and bite cells (B) are characteristic of Heinz body-mediated hemolysis. Blister cells appear to have a par...