Hemolytic disease of a fetus or newborn (HDFN) occurs due to the destruction of fetal and newborn red blood cells (RBCs) by maternal antibodies passively transferred across the place...
Maternal exposure to incompatible blood products
Previous stillbirths and/or abortions
Neonatal hyperbilirubinemia requiring exchange transfusion in previous pregnancy
RhIG not given aft...
Antenatal
Serial fetal monitoring
Intrauterine RBC transfusion: for severely affected fetuses (fetal Hct <25–30%) where early delivery is not possible; usually performed aft...
Hgb/Hct and reticulocyte count every 1 to 2 weeks for first 2 to 3 months, especially for infants who had exchange transfusion, due to risk of l...
Garabedian C, Rakza T, Drumez E, et al. Benefits of delayed cord clamping in red blood cell alloimmunization. Pediatrics. 2016;137(3):e20153236. [View Abstract on OvidInsights...
773.1 Hemolytic disease of fetus or newborn due to ABO isoimmunization
773.0 Hemolytic disease of fetus or newborn due to Rh isoimmunization
773.2 Hemolytic disease of fetus or newborn due to ...
Q: Why does the Rh isoimmunization become worse with each pregnancy?
A: Most sensitizing fetomaternal hemorrhages occur at delivery. In the first exposure, mother produces IgM antibodies, which doe...
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Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia Increased reticulocytes Schistocytes Polychromatophilia Peripheral Smear
Microangiopathic Hemolytic Anemia White cells Not remarkable Platelets Decreased Red cells Normocytic, normochromic anemia ...