Hemolytic uremic syndrome (HUS) is characterized by the triad of acute kidney injury, thrombocytopenia, and hemolytic anemia with fragmentation of erythrocytes (schistocytes noted on...
GI prodrome: STEC-HUS typically develops 5 to 13 days after the onset of diarrhea (usually bloody). There can be associated vomiting and fever.
Symptoms of pneumonia or meningitis: S. ...
Treatment of STEC-HUS is generally supportive. The mainstay of therapy involves the following:
Strict fluid balance
Nutritional support
Control of hypertension
Treatment of seizu...
Resolution is usually heralded by a rise in platelet count and a gradual decrease in the frequency of blood transfusions.
Pancreatic insufficiency may persist, req...
Joseph C, Gattineni J. Complement disorders and hemolytic uremic syndrome. Curr Opin Pediatr. 2013;25(2):209–215. [View Abstract on OvidInsights]
Loirat C, Fakhouri F, Ariceta ...
111407006 Hemolytic uremic syndrome (disorder)
36568005 Hemolytic uremic syndrome of childhood
Q: What factors should raise concern for aHUS?
A: Age <6 months at presentation, insidious onset, relapsing disease, or failure to identify STEC or Stx in the stool
Q: How many patients with gast...
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<bold>FIGURE 17-2</bold> <bold><i>Escherichia coli</i> with distinctive interactions with host cells. A.</bold> Electron micrograph of colon infected with the EHEC strain O157:H7. Notice the attaching bacteria and the altered epithelial cell membrane beneath them showing intimate attachment and "pedestal" formation. This attaching and effacing lesion is associated with EHEC and EPEC expressing the <i>eae</i> gene complex. (Original magnification, 3 28,5...
<bold>FIGURE 17-2</bold> <bold><i>Escherichia coli</i> with distinctive interactions with host cells. A....