Hemophilia A is factor VIII deficiency, and hemophilia B is factor IX deficiency.
Deficiency or absence of factor VIII or factor IX leads to a delay and disruption of blood clotting t...
Family history
Familial history of hemophilia in male offspring of female blood relatives is present in only 70% of cases.
Excessive bleeding in a male neonate
Excessive bleeding with ci...
Joint hemorrhage
Factor replacement
Immobilization: splints, casts, crutches, and/or bed rest (24 to 48 hours)
Prolonged immobilization may reduce recovery of joint ROM.
Initiati...
Complications of disease:
Hemophilic arthropathy: Repeated joint hemorrhages lead to synovial thickening and joint cartilage erosion. Joint space becomes narrowed and eventual...
Ljung RC. Intracranial haemorrhage in haemophilia A and B. Br J Haematol. 2008;140(4):378–384. [View Abstract on OvidInsights]
Pruthi RK. Hemophilia: a practical approach to ge...
286.0 Congenital factor VIII disorder
286.1 Congenital factor IX disorder
286.2 Congenital factor XI deficiency
D66 Hereditary factor VIII deficiency
D67 Hereditary factor IX deficiency
D68....
Q: Are there any medications contraindicated in a child with hemophilia?
A: Aspirin should not be given as it interferes with platelet function. NSAIDs cause a milder effect on platelets and should...
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Figure 13-15 <bold>HEMOPHILIA: POLYARTICULAR INVOLVEMENT.A and B. Knee. C. Ankle. D. Shoulder. E. Elbow. F. Wrist.</bold> Note that the characteristic features of hemophilic arthropathy are visible in multiple joints in severe,long-standing cases.Observe the destruction of the articular surfaces,regional osteopenia,and secondary degenerative changes(subchondral sclerosis and cyst formation often are congruent with the patient's age).
Figure 13-15 <bold>HEMOPHILIA: POLYARTICULAR INVOLVEMENT.A and B. Knee. C. Ankle. D. Shoulder. E. Elbow. F. Wrist.</bold> Note...