Histiocytic disorders are derived from mononuclear phagocytic cells and dendritic cells. They are divided into three groups.
Dendritic cell disorders (e.g., Langerhans cell histiocyto...
Signs and symptoms:
Wide variation in presenting signs and symptoms depending on affected organ systems
Single-system skeletal disease may be asymptomatic, with incidental discovery of ...
Site and extent of disease determine therapy.
A multidisciplinary approach is imperative to ensure the best therapy. Patients should be enrolled on a clinical trial whenever p...
Evaluation at regular intervals for recurrence of lesions or new high-risk organ involvement
Because of variable course, patients should be followed closely at cen...
Badalian-Very G, Vergilio JA, Fleming M, et al. Pathogenesis of Langerhans cell histiocytosis. Annu Rev Pathol. 2013;8:1–20. [View Abstract on OvidInsights]
Filipovich A, McCla...
277.89 Other specified disorders of metabolism
202.50 Letterer-siwe disease, unspecified site, extranodal and solid organ sites
C96.6 Unifocal Langerhans-cell histiocytosis
C96.0 Multifoca...
Q: Is LCH a cancer?
A: Historically, there has been controversy as to whether LCH was a cancer or an inflammatory disease. The discovery of BRAFV600E mutations has led to the conclusion that LCH is...
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