Histoplasmosis (a.k.a., Ohio Valley disease, spelunker’s lung, cave disease, Darling disease, Appalachian Mountain disease, and reticuloendothelial cytomycosis) is the most prevalent...
Of 5% who develop symptoms, most (60–90%) have pulmonary symptoms and/or flu-like illness lasting days to 2 weeks for acute.
Most common complaints: headache, fatigue, fever, cough, my...
Immunocompetent patients with primary acute uncomplicated (nonsevere) pulmonary histoplasmosis <4 weeks’ dur...
In PDH, follow antigen levels monthly during therapy and 12 months posttherapy.
Itraconazole blood levels should be measured after >2 weeks of...
Azar MM, Hage CA. Laboratory diagnostics for histoplasmosis. J Clin Microbiol. 2017;55(6):1612–1620. [View Abstract on OvidInsights]
Fischer GB, Mocelin H, Severo CB, et al. Hi...
115.90 Histoplasmosis, unspecified, without mention of manifestation
115.00 Infection by Histoplasma capsulatum, without mention of manifestation
115.05 Infection by Histoplasma capsulatum, pn...
Q: What are the most common clinical presentations of histoplasmosis?
A: Asymptomatic, mild primary pulmonary disease. Moderate to severe pulmonary, disseminated, and cavitary are uncommon.
Q: How i...
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Histoplasmosis. A section of lung shows an encapsulated, subpleural, fibrocaseous nodule.
Histoplasmosis. A section of liver from a patient with disseminated histoplasmosis reveals Kupffer cells containing numerous yeasts of H. capsulatum (PAS stain).
Histoplasmosis. A section of liver from a patient with disseminated histoplasmosis reveals Kupffer cells containing numerous yeasts of H. ...
FIGURE 19.4. Bone marrow aspirate from a patient with AIDS and progressive disseminated histoplasmosis. Highly characteristic image shows macrophage filled with 1- to 2mu m yeast cells (Wright stain, original magnification X400).
FIGURE 19.4. Bone marrow aspirate from a patient with AIDS and progressive disseminated histoplasmosis. Highly characteristic image shows ...
<bold>FIGURE 47-1</bold> <bold>Patchy pneumonitis and hilar lymphadenopathy typical of acute pulmonary histoplasmosis in an immunocompetent host.</bold>
<bold>FIGURE 47-1</bold> <bold>Patchy pneumonitis and hilar lymphadenopathy typical of acute pulmonary histoplasmosis i...
<bold>FIGURE 47-3</bold> <bold>Chronic cavitary pulmonary histoplasmosis with bilateral cavitary upper-lobe infiltrates and lower-lobe scarring.</bold>
<bold>FIGURE 47-3</bold> <bold>Chronic cavitary pulmonary histoplasmosis with bilateral cavitary upper-lobe infiltrates...
Figure 8.31. Presumed ocular histoplasmosis syndrome. The classic findings of juxtapapillary chorioretinal scars and macular scarring, with a greenish yellow area and blood along the edge, fulfill the clinical picture of choroidal neovascularization. Peripheral scars are often seen.
Figure 8.31. Presumed ocular histoplasmosis syndrome. The classic findings of juxtapapillary chorioretinal scars and macular scarring, wit...
<bold>Fig C 17-2 Histoplasmosis.</bold> Diffuse calcifications in the lungs produce a snowball pattern.
<bold>Fig GI 51-1 Histoplasmosis.</bold> CT scan shows multiple small calcifications in the spleen.
Figure 54.1. Upper lobe cavitary lesion in person with chronic pulmonary histoplasmosis. (Courtesy of Harriet Provine, Harvard Medical School, Boston, MA.)
Figure 54.1. Upper lobe cavitary lesion in person with chronic pulmonary histoplasmosis. (Courtesy of Harriet Provine, Harvard Medical Sch...
Figure 270.5. Chest roentgenogram of a patient with disseminated histoplasmosis showing diffuse interstitial alveolar infiltrates.
Histoplasmosis White cells Normal to increased Red cells Anemia in severe infections Platelets Not remarkable Small oval yeast forms may be seen within macrophages or monocytes on peripheral blood, bone marrow or buffy coat smears Peripheral Smear
Histoplasmosis White cells Normal to increased Red cells Anemia in severe infections Platelets Not remarkable Small oval ...
Peripapillary scarring in ocular histoplasmosis syndrome.