Immune thrombocytopenic purpura (ITP) is an autoimmune syndrome characterized by the following:
Isolated thrombocytopenia (platelet count formally <100,000/mm3, typically <20,00...
Presents with increased bruising (with minor or no trauma, or in uncommon locations such as torso, neck, face), petechiae, epistaxis, prolonged bleeding with minor trauma, gingival bl...
Because severe hemorrhage is rare and ITP resolves spontaneously in 90% of pediatric cases, most children without severe bleeding will not require treatment.
Treatment slows antibody-mediated...
Platelet count 1 to 2 times weekly when <20,000/mm3, biweekly when <50,000/mm3 or after treatment, except in stable chronic ITP. More freq...
Arnold DM. Bleeding complications in immune thrombocytopenia. Hematology Am Soc Hematol Educ Program. 2015;2015:237–242. [View Abstract on OvidInsights]
Eberl W, Dickerhoff R; ...
287.31 Immune thrombocytopenic purpura
287.32 Evans’ syndrome
287.3 Primary thrombocytopenia
D69.3 Immune thrombocytopenic purpura
D69.41 Evans syndrome
32273002 Idiopathic thrombocyto...
Q: Do children with ITP and very low platelet counts (<10,000/mm3) require prophylactic treatment?
A: Although there is some evidence that bleeding risk is higher with platelet counts <10,000...
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Idiopathic thrombocytopenic purpura. A section of the bone marrow reveals increased megakaryocytes.
FIG. 10.15. Hemorrhagic bullae of the lips (A) and petechiae on the tongue (B) mark the presentation of this child with idiopathic thrombocytopenic purpura.
FIG. 10.15. Hemorrhagic bullae of the lips (A) and petechiae on the tongue (B) mark the presentation of this child with idiopathic thrombo...
FIG. 10.15. Hemorrhagic bullae of the lips (A) and petechiae on the tongue (B) mark the presentation of this child with idiopathic thromboc...
<bold>Figure 67-8</bold> Petechiae and ecchymoses in a patient with idiopathic thrombocytopenic purpura. (Courtesy of Sidney Sussman, MD.)
<bold>Figure 67-8</bold> Petechiae and ecchymoses in a patient with idiopathic thrombocytopenic purpura. (Courtesy of Sidney Su...