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Immune Deficiency, Pediatric

Kathleen E. Sullivan, MD, PhD Reviewed 10/2018
 


BASICS

DESCRIPTION

Immunodeficiencies generally represent a defect in host defense. Less common deficiencies represent defects in the regulation of immune function. Congenital and acquired forms exist....

DIAGNOSIS

HISTORY

  • Question: Family history?

  • Significance: X-linked disorders are common.

  • Question: Number and duration of infections?

  • Significance: to determine whether the problem is one of clearance or ...

TREATMENT

Prophylactic antimicrobials 
  • Chronic mucocutaneous candidiasis

  • Hyper-IgE syndrome

  • CGD

GENERAL MEASURES

  • Suspected SCID requires isolation, cytomegalovirus-negative/irradiated blood products, and a...

ONGOING CARE

PROGNOSIS

  • Most antibody deficiencies have an excellent prognosis. Transient or developmental deficiencies of IgG or IgG subclasses typically resolve by 2 years of age.

  • Some patients with CV...

ADDITIONAL READING

  • Ballow M. Approach to the patient with recurrent infections. Clin Rev Allergy Immunol.  2008;34(2):129–140. [View Abstract on OvidInsights]

  • Fischer A. Human primary immunodefici...

CODES

ICD9

  • 279.3 Unspecified immunity deficiency

  • 279.03 Other selective immunoglobulin deficiencies

  • 279.06 Common variable immunodeficiency

  • 279.04 Congenital hypogammaglobulinemia

  • 279.8 Other specified dis...

FAQ

  • Q: Does a child with thrush require evaluation?

  • A: A child with severe thrush in the absence of risk factors should have an evaluation for T-cell dysfunction, HIV, and the possibility of chronic mu...

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