Immunoglobulin A Deficiency, Pediatric

Increased susceptibility to infection

Autoimmune manifestations

Serum IgA <7 mg/dL and a norma...

Patients with IgA deficiency

• Can have recurrent sinopulmonary infections

• Can have frequent GI infections

• Tend to have atopic disease such as allergic rhinitis, allergic conjunctivitis, u...

There is no specific drug therapy.

Recurrent infections should be treated aggressively with broad-spectrum antibiotics.

Antibiotic prophylaxis to prevent recurrent sinopulmonar...

Patients should be observed for the following:

• Sinopulmonary infections, particularly signs/symptoms of bronchiectasis

• GI infections

• Autoimmune diseases

• Inflammatory ...

Burrows PD, Cooper MD. IgA deficiency. Adv Immunol.  1997;65:245–276. [View Abstract on OvidInsights]

Janzi M, Kull I, Sjöberg R, et al. Selective IgA deficiency in early life: ...

Q: Should patients with IgA deficiency be monitored for the development of progressive immunodeficiency?

A: Patients with IgA deficiency should be monitored for progression to CVID, as this is asso...