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Neonatal Alloimmune Thrombocytopenia, Pediatric

Anne M. Marsh, MD and Alison T. Matsunaga, MD Reviewed 10/2018
 


BASICS

DESCRIPTION

Neonatal alloimmune thrombocytopenia (NAIT) is one of the major causes of severe thrombocytopenia in the newborn. 
  • Analogous to ABO/Rh incompatibility but involves platelets instead o...

DIAGNOSIS

HISTORY

  • NAIT is suspected in a non–ill-appearing neonate who presents shortly after birth with clinical signs of bleeding and documented thrombocytopenia.

  • Patient may have a history of mild ea...

TREATMENT

GENERAL MEASURES

  • Daily platelet counts should be obtained until there is documentation of improvement without treatment/intervention.

  • Close monitoring for any evidence of bleeding complication...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Given the implications for future pregnancies, NAIT testing should be considered in all infants with thrombocytopenia (<50 × 109/L), even if there is another l...

ADDITIONAL READING

  • Crighton GL, Scarborough R, McQuilten ZK, et al. Contemporary management of neonatal alloimmune thrombocytopenia: good outcomes in the intravenous immunoglobulin era: results from t...

CODES

ICD9

  • 776.1 Transient neonatal thrombocytopenia

  • 287.33 Congenital and hereditary thrombocytopenic purpura

ICD10

  • P61.0 Transient neonatal thrombocytopenia

  • D69.42 Congenital and hereditary thrombocytope...

FAQ

  • Q: Can an infant with NAIT safely receive maternal breast milk (MBM)?

  • A: Colostrum and MBM contain immunoglobulins that are passively transferred to an infant. In a pregnancy affected by NAIT, this...

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