Neuroblastoma is a “small round blue cell tumor” of childhood which arises from developing neural crest cells in the sympathetic nervous system.
The clinical behavior of neuroblastoma...
Patients with low-risk disease often appear well, and the tumor is discovered incidentally on exam or imaging studies for other reasons.
High-risk patients often are ill-appearing with...
Treatment is based on risk stratification using age 18 months, stage, DNA ploidy, favorable versus unfavorable histology, and genomic features (presence or absence of segmental copy number a...
On therapy
Laboratory monitoring f...
Bagatell R, Cohn SL. Genetic discoveries and treatment advances in neuroblastoma. Curr Opin Pediatr. 2016;28(1):19–25. [View Abstract on OvidInsights]
Maris JM. Recent advances...
194.0 Malignant neoplasm of adrenal gland
158.0 Malignant neoplasm of retroperitoneum
164.9 Malignant neoplasm of mediastinum, part unspecified
195.2 Malignant neoplasm of abdomen
195.1 Malignan...
Q: Are siblings of children with neuroblastoma at increased risk for neuroblastoma compared with the general population?
A: No, except in rare families with a known history of neuroblastoma (<1%...
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FIGURE 118.20. <bold>A:</bold> Celiac axis neuroblastoma. Computed tomographic (CT) section of the abdomen shows a large lobulated mass with multiple flakes of calcification displacing stomach and the liver <italic>(white arrow).</bold> Note presence of retrocrural node <italic>(black arrows).</bold> A, aorta; L, liver; N, node; S, stomach. <bold>B:</bold> Celiac axis neuroblastoma. Enhanced CT section of the abdomen at level of the kidney shows a large lobulated mass with irregular margins and calcification displacin...
FIGURE 118.20. <bold>A:</bold> Celiac axis neuroblastoma. Computed tomographic (CT) section of the abdomen shows a large lobul...
FIG. 10.33. Dumbbell neuroblastoma. A: Magnetic resonance T1-weighted coronal image. Note the small adrenal tumor (arrows) just medial to the ipsilateral kidney. B: A slightly more posterior cut demonstrates the tumor extending into the spinal canal (arrows).
FIG. 10.33. Dumbbell neuroblastoma. A: Magnetic resonance T1-weighted coronal image. Note the small adrenal tumor (arrows) just medial to ...
<bold>FIGURE 21-41. Neuroblastoma.</bold> <bold>A.</bold> A large, lobulated, hemorrhagic, and cystic tumor, adherent to the upper pole of the kidney, was removed from a child who presented with an abdominal mass. <bold>B.</bold> A photomicrograph illustrates the characteristic rosettes, formed by small, regular, dark tumor cells arranged around a central, pale fibrillar core.
<bold>FIGURE 21-41. Neuroblastoma.</bold> <bold>A.</bold> A large, lobulated, hemorrhagic, and cystic tumor, adher...