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Neutropenia, Pediatric

Kristin A. Shimano, MD Reviewed 10/2018
 


BASICS

DESCRIPTION

A decrease in the number of circulating neutrophils (both segmented and band forms), strictly defined as an absolute total neutrophil count (ANC) of <1,500/μL in children >1 ye...

DIAGNOSIS

HISTORY

  • Recent or current viral infection

  • Current or recurrent fever, skin abscesses, infections, or oral ulceration

  • Temporal pattern of symptoms

  • Symptoms of malabsorption, such as diarrhea or f...

TREATMENT

GENERAL MEASURES

  • Correction of underlying cause of neutropenia (discontinue drug, treat infection, correct nutritional deficiency)

  • Treatment of fever and suspected infection when neutropenic: ...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

Management of febrile episodes (depends on etiology of neutropenia) 
  • Prompt evaluation by a physician.

  • Obtain CBC with differential and blood culture.

  • Treat with IV ...

ADDITIONAL READING

  • Fioredda F, Calvillo M, Bonanomi S, et al. Congenital and acquired neutropenia consensus guidelines on diagnosis from the Neutropenia Committee of the Marrow Failure Syndrome Group ...

CODES

ICD9

  • 288.00 Neutropenia, unspecified

  • 288.01 Congenital neutropenia

  • 288.02 Cyclic neutropenia

  • 288.04 Neutropenia due to infection

  • 288.03 Drug induced neutropenia

ICD10

  • D70.9 Neutropenia, unspecified

  • D70....

FAQ

  • Q: Do all patients with neutropenia require G-CSF?

  • A: No. Patients with severe congenital neutropenia have fewer infections when treated with G-CSF. Patients with benign neutropenia generally do no...

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