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Non-Hodgkin Lymphoma, Pediatric

Michelle L. Hermiston, MD, PhD Reviewed 10/2018
 


BASICS

DESCRIPTION

  • Non-Hodgkin lymphoma (NHL) arises from the malignant proliferation of developing or mature B or T lymphocytes.

  • Extent of disease is determined using the Murphy staging system:

    • Stage I:...

DIAGNOSIS

HISTORY

  • Mature B-cell lymphomas

    • Systemic manifestation (e.g., fever, weight loss, anorexia, fatigue) if disseminated; less likely if tumor localized

    • Abdominal mass with pain, swelling, change i...

TREATMENT

GENERAL MEASURES

  • Pathologic diagnosis, site, and extent of disease determine therapy.

  • A multidisciplinary approach is imperative to ensure the best therapy.

  • Patients should be enrolled on clini...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Patient monitoring weekly to monthly with CBC and physical examination

  • Radiologic imaging at intervals during and off therapy

Patient Monitoring

Late effects from th...

ADDITIONAL READING

  • Abramson SJ, Price AP. Imaging of pediatric lymphomas. Radiol Clin North Am.  2008;46(2):313–338. [View Abstract on OvidInsights]

  • Bollard CM, Lim MS, Gross TG; for COG Non-Hodgk...

CODES

ICD9

  • 202.80 Other malignant lymphomas, unspecified site, extranodal and solid organ sites

  • 200.20 Burkitt’s tumor or lymphoma, unspecified site, extranodal and solid organ sites

  • 200.60 Anaplastic la...

FAQ

  • Q: Did I do something to cause this?

  • A: No. Most cases are sporadic and not associated with diet, underlying immune dysfunction, or viral illness.

  • Q: Is this contagious?

  • A: No. Siblings may have slig...

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