Clinical severity variable and dependent in part on the nature of the molecular l...
Widely varied; may include recurrent fractures including fractures with little or no predisposing trauma
May have positive family history. Proportion of people who have OI and have a f...
Intramedullary rodding with or without osteotomies:
Often performed as early as 18 months of age, but timing depends on several considerations including size of the patient/bo...
Pediatric endocrinologist, geneticist, or other metabolic bone specialist
Medical management of OI
Pediatric orthopedic...
Forlino A, Marini JC. Osteogenesis imperfecta. Lancet. 2016;387(10028):1657–1671. [View Abstract on OvidInsights]
Glorieux FH, Moffatt P. Osteogenesis imperfecta, an ever-expan...
78314001 Osteogenesis imperfecta (disorder)
385482004 osteogenesis imperfecta type I (disorder)
205496008 osteogenesis i...
Q: What is the typical life expectancy for persons with OI?
A: Infants with perinatal/lethal (type II) OI do not survive the perinatal period and often die within the first 48 hours of life. For mi...
Sign up for a 10-day FREE Trial now and receive full access to all content.
<bold>Fig B 23-4. Osteogenesis imperfecta.</bold> The bones of the lower extremity are thin and deformed with evidence of previous fracture.
<bold>Fig B 23-4. Osteogenesis imperfecta.</bold> The bones of the lower extremity are thin and deformed with evidence of prev...