Pain and palpable mass are the most common clinical symptoms.
Pain is often described as dull or aching at the tumor site.
Pain is often initially attributed to an injury in active chil...
Prior to the 1970s, overall survival for high-grade osteosarcoma was poor, as treatment primarily consisted of surgical resection allowing for relapse with metastatic disease. With...
Patients should be followed by a pediatric oncologist with serial imaging of the primary site (MRI and/or radiographs) and lungs (chest CT or ch...
Bielack SS, Carrle D, Hardes J, et al. Bone tumors in adolescents and young adults. Curr Treat Options Oncol. 2008;9(1):67–80. [View Abstract on OvidInsights]
Bielack SS, Smela...
170.9 Malignant neoplasm of bone and articular cartilage, site unspecified
170.7 Malignant neoplasm of long bones of lower limb
170.4 Malignant neoplasm of scapula and long bones of upper limb
...
Q: How can we differentiate between malignant osteosarcoma and benign tumors?
A: An experienced radiologist can look for defining features on imaging of malignant osteosarcoma that are not found wi...
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Cytology figure of osteosarcoma showing tumor cells including a multinucleated cell.
Osteosarcoma showing osteoid formation with cytologically malignant cells.
Higher power of osteosarcoma showing pleomorphic spindle cells and multinucleated cells with osteoid formation.
Figure 58.2. Increased bone density in the distal femur. In this patient, the anteroposterior radiograph shows the neoplasm more clearly.
FIGURE 115.13. Radiograph of a 5-year-old girl with an osteosarcoma of the left femur showing an acute pathologic fracture <italic>(arrows).</bold> Amputation was ultimately necessary.
FIGURE 115.13. Radiograph of a 5-year-old girl with an osteosarcoma of the left femur showing an acute pathologic fracture <italic>(...
Figure 11-101 <bold>THE RADIOGRAPHIC APPEARANCE OF LYTIC VERSUS SCLEROTIC OSTEOSARCOMA. A. Lytic Presentation:Proximal Humerus.</bold> Note the focal lesion in the metaphysis of the proximal humerus, demonstrating mottled, permeative destruction. This appearance is characteristic of a lytic presentation in osteosarcoma. <bold>B. Sclerotic Presentation:Proximal Humerus.</bold> Note the dense radiopaque appearance to the humeral head and its metaphysis. A large soft tissue mass and spiculated periosteal ...
Figure 11-101 <bold>THE RADIOGRAPHIC APPEARANCE OF LYTIC VERSUS SCLEROTIC OSTEOSARCOMA. A. Lytic Presentation:Proximal Humerus.</...
<bold>FIGURE 119.18</bold> Plain radiograph of the femur showing a high-grade osteosarcoma. The tumor is an ill-defined destructive lesion with an extensive soft tissue component. Codman's triangles are present (<italic>arrows</bold>).
<bold>FIGURE 119.18</bold> Plain radiograph of the femur showing a high-grade osteosarcoma. The tumor is an ill-defined destru...
<bold>Figure 11.54. Relationship of lesions to the physis. A,</bold> osteosarcoma extends down to the physis but does not cross it. <bold>B,</bold> tuberculous osteomyelitis has produced cystic lesions (*) on both sides of the physis. The ankle joint is still not crossed.
<bold>Figure 11.54. Relationship of lesions to the physis. A,</bold> osteosarcoma extends down to the physis but does not cros...
<bold>FIGURE 26-43. Osteosarcoma.</bold> <bold>A.</bold> The distal femur contains a dense osteoblastic malignant tumor that extends through the cortex into the soft tissue and the epiphysis. <bold>B.</bold> A photomicrograph reveals pleomorphic malignant cells, tumor giant cells, and mitoses. The tumor produces woven bone that is focally calcified.
<bold>FIGURE 26-43. Osteosarcoma.</bold> <bold>A.</bold> The distal femur contains a dense osteoblastic malignant ...
Figure 58.1. A destructive bone-forming lesion of the distal femoral metaphysis. Notice the destruction of the medial femoral condyle, the new bone formation in the region of bone destruction, and the elevation of the periosteum. These features are characteristic of osteosarcomas.
Figure 58.1. A destructive bone-forming lesion of the distal femoral metaphysis. Notice the destruction of the medial femoral condyle, the...
Osteosarcoma. (A) The distal femur contains a dense osteoblastic malignant tumor that extends through the cortex into the soft tissue and the epiphysis. (B) A photomicrograph reveals pleomorphic malignant cells, tumor giant cells, and mitoses. The tumor produces woven bone that is focally calcified.
Osteosarcoma. (A) The distal femur contains a dense osteoblastic malignant tumor that extends through the cortex into the soft tissue and t...