In most populations, the mean ages of onset of puberty are 10.5 years in girls and 11.5 years in boys.
Girls: The first sign of puberty is most commonly breast development (thelarche)...
Careful history focusing on chronology: physical changes, growth spurt, onset of menses
Neurologic, visual, or behavioral changes suggest a CNS lesion.
Family history...
Central precocious puberty: GnRH agonists (leuprolide depot injection or histrelin acetate implant) are treatment of choice. Adjunctive therapy with growth hormone may be needed to...
When to expect improvement:
Depends on cause. For example, sexual changes of McCune-Albright syndrome are due to autonomously functioning ovarian cysts, which regress variably over time.
Tr...
Carel JC, Eugster EA, Rogol A, et al; for ESPE-LWPES GnRH Analogs Consensus Conference Group. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. P...
259.1 Precocious sexual development and puberty, not elsewhere classified
253.1 Other and unspecified anterior pituitary hyperfunction
E30.1 Precocious puberty
E22.8 Other hyperfunction of...
Q: If my child is treated with a GnRH agonist, will he or she go through puberty when we stop the medication?
A: Yes. Children on GnRH agonist treatment proceed through normal puberty when the medi...
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