Etiologic agent: Treponema pallidum
Can be congenital or acquired
Consider sexual abuse when syphilis diagnosed in young children.
All confirmed cases should be reported to the local pu...
Congenital syphilis
Clinical manifestations range from clinically unapparent to stillbirth (see “Physical Exam”).
Acquired syphilis
Primary stage: chancre, single or multiple, at the site of in...
Infants with proven or highly probably disease:
Infants <28 days of age
Aqueous crystalline penicillin G (50,000 U/kg/dose) IV q12h for first 7 days of age and then q8h for a total of 10 da...
Careful follow-up examinations and serologic testing (i.e., a nontreponemal test) of infants and children should be performed...
American Academy of Pediatrics. Syphilis. In: Kimberlin DW, Brady MT, Jackson MA, et al, eds. Red Book: 2015 Report of the Committee on Infectious Diseases. 30th ed. Elk Grove Vill...
097.9 Syphilis, unspecified
090.9 Congenital syphilis, unspecified
092.9 Early syphilis, latent, unspecified
097.0 Late syphilis, unspecified
097.1 Latent syphilis, unspecified
A53.9 Syphili...
Q: What is the prozone phenomenon?
A: When a nontreponemal test is falsely negative due to high concentrations of nontreponemal IgG antibody; diluting the serum will result in a positive test resul...
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<bold>FIGURE 2-10.</bold> The illusion of depth when using scanning electron microscopy clearly reveals the corkscrew shape of cells of the syphilis-causing spirochete, <italic>Treponema pallidum</bold>.
<bold>FIGURE 2-10.</bold> The illusion of depth when using scanning electron microscopy clearly reveals the corkscrew shape of ...
<bold><italic>Figure 20-19</bold> Syphilitic aortitis in tertiary syphilis. A,</bold> The aortic root is dilated, so that the valve does not seal properly during diastole (regurgitation), and the valve leaflets are thickened because of chronic inflammation and scarring. <bold>B,</bold> Marked left ventricular dilation and hypertrophy caused by aortic regurgitation associated with dilation of aortic root.
<bold><italic>Figure 20-19</bold> Syphilitic aortitis in tertiary syphilis. A,</bold> The aortic root is dilated, s...