Issues with presentation of disease:
WD has a variable presentation that requires a high level of suspicion.
45% of all patients present with liver disease, 35% with neurologic symptoms...
Lifetime therapy aimed at treating copper overload
Consists of two phases
(1) Removing or detoxifying the tissue copper (achieved by chelators)
(2) Preventing reaccumulation without leading to ...
Patients require lifelong dietary copper restriction and chelation therapy. Dosing of chelation therapy, although not zinc, needs to be adjusted...
Ala A, Walker AP, Ashkan K, et al. Wilson’s disease. Lancet. 2007;369(9559):397–408. [View Abstract on OvidInsights]
Brewer GJ, Askari F, Dick RB, et al. Treatment of Wilson’s ...
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