Class of sedative–hypnotic agents
Derivatives of barbituric acid
Enhances activity of γ-aminobutyric acid (GABA)
At high levels, directly opens GABA-A associated chloride chan...
Coma (can mimic brain death)
Loss of reflexes
Miosis (generally associated w...
Moderate to severe poisonings require paramedic transport.
Intubation is often necessary because of respiratory depression or loss of gag reflex.
IV access and supplemental oxygen:
Hypothermia may be pronounced:
Ensure accurate core temperature is measured.
Check for rhabdomyolysis, since the patient may have been down for a while.
Barbiturate poisoning can caus...
Lee DC, Ferguson KL. Sedative-hypnotic agents. In: Nelson LS, Lewin NA, Howland MA, et al., eds. Goldfrank's Toxicologic Emergencies. 9th ed. New York, NY: McGraw-Hill; 2010.
T42.3X1A Poisoning by barbiturates, accidental (unintentional), init
T42.3X2A Poisoning by barbiturates, intentional self-harm, init
T42.3X4A Poisoning by ...
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