Patient on anticoagulant medications with minor, major, or clinically significant bleeding needing close monitoring +/− anticoagulant reversal
Patient on anticoagulants with active bleeding
Indications for reversal
Serious or life-threatening bleeding
Intracerebral hemorrhage (ICH)
Pressure to hemorrhage (if possible)
2 large-bore IVs
Same as pre-hospital
Indirect inhibitors of thr...
Clinically significant bleeding
Utilization of reversal agents
Insignificant bleeding that is controlled without the use of anticoagulant reversa...
Prophylactic heparin dosing does not typically confer an increased risk of major bleeding
LMWH is not always reversed with protamine—it is compound specific
If >12 hr have elapsed...
Ageno W, Gallus AS, Wittkowsky A, et al. Oral anticoagulant therapy: Antithrombotic therapy and prevention of thrombosis. Chest. 2012;141:e44S–e88S.
Tawil I, Seder D, Dupr...
286.6 Defibrination syndrome
286.9 Other and unspecified coagulation defects
V58.61 Long-term (current) use of anticoagulants
287.1 Qualitative platelet defects
D65 Disseminated intravascul...
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