Disorder in which large volumes of dilute urine are excreted (polyuria) as an inappropriate response to argininevasopressin (AVP)
Polyuria defined as >3 L in 24 hr
Polyuria (up to 16–24 L/d of urine):
Note the voiding frequency.
Polydipsia (often craves cold fluids):
Note the amount of PO fluid intake per day.
Immobilize if trauma is suspected.
Serum blood glucose
IV access and fluids if signs of dehydration exist
Control seizures according to medical direction guidelines.
Patients requiring DDAVP testing or a trial of water restriction
Check urine osmolality and consider DI in polyuria.
Central DI will typically respond to desmopressin.
Nephrogenic DI will not respond to ADH:
Treat the underlying electrolyte abnorma...
Di lorgi N, Napoli F, Allegri AE, et al. Diabetes insipidus – diagnosis and management. Horm Res Paediatr. 2012;77:69–84.
Fenske W, Allolio B. Current state and future per...
253.5 Diabetes insipidus
588.1 Nephrogenic diabetes insipidus
E23.2 Diabetes insipidus
N25.1 Nephrogenic diabetes insipidus
15771004 Diabetes insipidus (disorder)
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