A significant decrease in the number of granulocytes in the peripheral blood.
3 classes of granulocytes:
Neutrophils or polymorphonuclear (PMN) cells and bands
Signs of bacterial or fungal infection:
Localized erythema or fluctuance
Signs of pancytopenia:
Epistaxis and other spontaneous bleeding
Administer 1 L 0.9% NS IV fluid bolus (peds: 20 cc/kg).
Initiate pressors as needed to stabilize BP if no response to IV fluids.
Signs of infection
Usual signs of infection may be masked because of the impaired immune response in patients with granulocytopenia.
Rectal exams and rectal temperatures are relatively contraindicated...
Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious disea...
288.00 Neutropenia, unspecified
288.03 Drug induced neutropenia
288.09 Other neutropenia
288.01 Congenital neutropenia
288.02 Cyclic neutropenia
288.04 Neutropenia due to infection
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