Complexes with and inactivates pyridoxal-5 phosphate, the active form of pyridoxine (vitamin B6)
Inhibits pyridoxine phosphokinase, hindering the conversion of pyridoxine to its activ...
Altered mental status
Seizures refractory to standard therapy
Intubate if necessary for airway protection
Secure IV ac...
ICU admission for refractory seizures, severe acidosis, coma, altered mental status
Uncontrolled nausea/vomiting, unclear history of ingestion, or suicidal
Inadequate appreciation and management of INH poisoning:
Refractory seizures to standard treatments is a fundamental clue to INH poisoning
Severe acidemia with elevated lactate in al...
Minns AB, Ghafouri N, Clark RF. Isoniazid-induced status epilepticus in a pediatric patient after inadequate pyridoxine therapy. Pediatr Emerg Care. 2010;26:380–381.
T37.1X1A Poisoning by antimycobac drugs, accidental, init
T37.1X4A Poisoning by antimycobacterial drugs, undetermined, init
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