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Isopropanol Poisoning, Emergency Medicine

Paul Kolecki Reviewed 06/2017
 


Basics

Description

  • CNS depressant effect of isopropanol is 2 to 3 times as potent as that of ethanol.

  • Many products that contain isopropanol also contain methanol, ethylene glycol, and ethanol.

  • Rapidly a...

Diagnosis

Signs and Symptoms

  • Usually occur within 30–60 min of ingestion

  • Neurologic:

    • Lethargy

    • Weakness

    • Headache

    • Inebriation

    • Vertigo

    • Ataxia

    • Apnea

    • Coma

    • Initial excitation phase seen with ethanol ingestion is absen...

Treatment

Pre-Hospital

Search for and transport all bottles and medications that may have been ingested by the patient when an overdose is suspected. 

Initial Stabilization/Therapy

  • ABCs:

    • Maintain airway a...

Follow-Up

Disposition

Admission Criteria

Moderate to severe isopropanol toxicity (altered mental status, hypotension) 

Discharge Criteria

  • Observe asymptomatic patients following ingestion for 2–4 hr befor...

Pearls and Pitfalls

  • Supportive care is the primary treatment.

  • Do not treat with ethanol infusion or 4-methylpyrazole.

Additional Reading

  • Emadi  A, Coberly  L. Intoxication of a hospitalized patient with an isopropanol-based hand sanitizer. N Engl J Med.  2007;356:530–531.

  • Kraut  JA, Kurtz  I. Toxic alcohol ingest...

Codes

ICD9

  • 976.0 Poisoning by local anti-infectives and anti-inflammatory drugs

  • 980.2 Toxic effect of isopropyl alcohol

  • 982.8 Toxic effect of other nonpetroleum-based solvents

ICD10

  • T51.2X1A Toxic effect o...

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