Normal cells transform into myeloma cells at the hematopoietic stem cell level.
Tumor cells within marrow lead to bone destruction and cytopenia.
Bone pain predominates (with secondary disuse or neurologic sequelae):
Presume to have a pathologic spinal fracture
Refractory pain requiring systemic analgesics
Life-threatening complications of MM, including acute renal failure, hypercalcemia, sepsis, spinal cord compression,...
Infectious complications are the major cause of morbidity and mortality such that febrile illness should be treated with empiric therapy for common respiratory and urinary tract in...
Altundag K, Altundag O, Gundeslioglu O. Multiple myeloma. N Engl J Med. 2005;352:840–841.
Bladé J, Rosiñol L. Complications of multiple myeloma. Hematol Oncol Clin North A...
109989006 multiple myeloma (disorder)
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