Pathophysiology: Recurrent episodes of CNS demyelination:
Signs and symptoms depend on location of lesions and timing of demyelination
Multiple sclerosis (MS) occurs in distinct patter...
Initial attacks usually (∼85%) represent single lesions, are abrupt in onset, and are seen in characteristic patterns (in order of decreasing frequency):
Acute optic neuritis:
High-dose parenteral ster...
Acute exacerbation that requires IV therapy
Patients unable to care for themselves due to severity of their illness
Another condition requiring inpatient treatment...
Signs and symptoms of MS are usually focal
Diffuse symptoms are rarely MS
Oral steroids are contraindicated
Treat fever in MS patients aggressively
Balcer LJ. Clinical practice. Optic neuritis. N Eng J Med. 2006;354:1273–1280.
Burton JM, O’Connor PW, Hohol M, et al. Oral versus intravenous steroids for treatment of rel...
24700007 Multiple sclerosis (disorder)
230372003 Acute relapsing multiple sclerosis (disorder)
428700003 Primary progressive multiple s...
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