Life-threatening neurologic disorder most often caused by an adverse reaction to a neuroleptic or antipsychotic medication.
Mortality can be as high as 20%
May develop any time during ...
Hallmarks of the disease:
Hyperthermia (temperature may be as high as 106–107°F, 41°C)
Altered level of consciousness—stupor
Significant skeletal mus...
Ventilation may be difficult because of chest wall rigidity
Cool the patient and treat seizures if they occur
Check fingerstick glucose
Patients with NMS should be admitted
Patients will often require intensive care
Maintain high clinical suspicion for NMS in patients on neuroleptics with mental status changes, rigidity, fever, or dysautonomia
Must rule out other causes of fever and altered men...
Bellamy CJ, Kane-Gill SL, Falcione BA, et al. Neuroleptic malignant syndrome in traumatic brain injury patients treated with haloperidol. J Trauma. 2009;66:954–958.
15244003 Neuroleptic malignant syndrome (disorder)
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