Neuroleptics (antipsychotics) used for management of:
Dementia in the elderly
Autism and behavioral problems in children
Symptom onset within 6 hr, 9 hr with aripiprazole, up to 24 hr with extended-release formulations (paliperidone)
Can be delayed if anticholinergic symptoms pr...
Administer supplemental oxygen.
Overdose with CNS sedation, agitation, dysrhythmias, or vital sign abnormalities to monitored bed or ICU
NMS require ICU care
New-onset diabetes (secondary to neur...
Neuroleptics represent a group of drugs with diverse indications and a wide range of toxicity.
Most overdoses are mild, and CNS depression predominates.
Dystonic reactions are the mo...
Levine M, Ruha AM. Overdose of atypical antipsychotics: Clinical presentation, mechanisms of toxicity and management. CNS Drugs. 2012;26:601–611.
Lipscombe LL, Lévesque L, ...
969.1 Poisoning by phenothiazine-based tranquilizers
969.2 Poisoning by butyrophenone-based tranquilizers
969.3 Poisoning by other antipsychotics, neuroleptics, and major tranquilizers
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