Inhibit cyclooxygenase (COX), thereby blocking the conversion of arachidonic acid to prostaglandin.
Typically morbidity is low when an NSAID is ingested
Most literature on nonselective...
Naloxone, thiamine, dextrose (or Accu-Chek) for altered mental status
Protracted vomiting, hematemesis
CNS depression, seizure activity
CHF, hypotension, hypertension
Investigate for coingestions for all NSAID overdoses.
Obtain acetaminophen and salicylate level on all patients who present with suspected NSAID ingestion.
NSAID poisoning is general...
Dajani EZ, Islam K. Cardiovascular and gastrointes–tinal toxicity of selective cyclo-oxygenase-2 inhibitors in man. J Physiol Pharmacol. 2008;59(suppl 2):117–133.
Frei MY, N...
T39.391A Poisoning by other nonsteroidal anti-inflammatory drugs, accidental, init?
T39.392A Poisoning by other nonst...
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