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Reye Syndrome, Emergency Medicine

Reviewed 06/2017
 


Basics

Description

  • Reversible clinicopathologic syndrome of unknown etiology

  • Primary mitochondrial injury

  • Decreased enzyme activity:

    • Krebs cycle

    • Gluconeogenesis

    • Urea biosynthesis

  • Fatty infiltration:

    • Liver:

      • Hyp...

Diagnosis

Signs and Symptoms

  • Usually the patient is afebrile.

  • Tachycardia

  • Hyperventilation

History

  • Biphasic history marked by an infectious phase (viral illness or prodrome) followed by an encephalopathic ...

Treatment

Pre-Hospital

  • Decreased mental status:

    • Glucose

    • Narcan

  • Coma:

    • Assist respirations with bag-valve mask.

Initial Stabilization/Therapy

  • Place on a cardiorespiratory monitor.

  • Supplemental oxygen

  • Rapid-seque...

Follow-Up

Disposition

Admission Criteria

  • All children with suspected Reye syndrome should be admitted to the ICU.

  • Hospital capable of ICP monitoring

Discharge Criteria

Hospital discharge criteria are indiv...

Pearls and Pitfalls

  • Aspirin and salicylates are found in many medications and combination products.

  • All efforts must be directed at identifying other possible causes of illness in the patient with susp...

Additional Reading

  • Gosalakkal  JA, Kamoji  V. Reye syndrome and Reye-like syndrome. Pediatr Neurol.  2008;39:198–200.

  • Hurwitz  ES. Reye syndrome. In: Feigin  RD, Cherry  JD, Demmler-Harrison  GJ, ...

Codes

ICD9

331.81 Reye's syndrome 

ICD10

G93.7 Reye's syndrome 

SNOMED

  • 74351001 Reye's syndrome (disorder)

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