Thrombotic thrombocytopenic purpura (TTP) is a severe disorder of abnormal clotting affecting multiple organ systems.
Classically characterized by pentad of:
Platelet count <20,000/mm3
Microangiopathic and hemolytic anemia:
Hb <10 g/dL (<6 g/dL in 40%)
Evaluate for other possible causes of altered mental status (hypoglycemia, overdose)
0.9% normal saline (NS) IV fluid resuscitation for shock ...
Newly diagnosed serious platelet disorder, especially with bleeding complications or altered mental status or renal dysfunction
ICU admission for TTP with active ...
TTP can be confused with HELLP syndrome in pregnant females.
Because of the high mortality of untreated TTP, recognition of the disease and initiation of treatment is key.
George JN. Clinical practice. Thrombotic thrombocytopenic purpura. N Engl J Med. 2006;354:1927–1935.
George JN. How I treat patients with thrombotic thrombocytopenic purpura:...
78129009 Thrombotic thrombocytopenic purpura (disorder)
439007008 Acquired thrombotic thrombocytopenic purpura
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