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Acanthosis Nigricans

Jessica Gray, MD and Ronald L. Cook, DO, MBA Reviewed 06/2019
 


BASICS

DESCRIPTION

  • Acanthosis nigricans (AN) is a benign dermatosis characterized by velvety, hyperpigmented, hyperkeratotic plaques, which

    • Are usually symmetric

    • Most often occur on the posterior neck,...

DIAGNOSIS

HISTORY

  • Age of onset

    • Most common between the ages of 11 and 40 years

    • Occurrence in infancy suggests familial or syndromic AN.

    • Malignant AN is more common in older adults.

  • Past medical history

    • ...

TREATMENT

GENERAL MEASURES

  • Improvement of AN in obese individuals who succeed at weight loss

  • Discontinue offending drugs in drug-induced AN (1)[B].

  • Improvement of malignant AN with treatment of underlyin...

ONGOING CARE

FOLLOW-UP RECOMMENDATIONS

  • Close monitoring of BMI, glycohemoglobin, and blood pressure in obese individuals and those with insulin resistance

  • Close follow-up and appropriate interventions i...

REFERENCES

1
Puri N. A study of pathogenesis of acanthosis nigricans and its clinical implications. Indian J Dermatol.  2011;56(6):678–683. [View Abstract on OvidMedline]
2
Barbato MT, Criado PR, Si...

ADDITIONAL READING

  • Romo A, Benavides S. Treatment options in insulin resistance obesity-related acanthosis nigricans. Ann Pharmacother.  2008;42(7):1090–1094. [View Abstract on OvidMedline]

  • Zhang ...

CODES

ICD10

  • L83 Acanthosis nigricans

  • Q82.8 Other specified congenital malformations of skin

ICD9

  • 701.2 Acquired acanthosis nigricans

  • 757.39 Other specified anomalies of skin

SNOMED

  • 72129000 acquired acanthos...

CLINICAL PEARLS

  • AN is a benign dermatosis that is commonly associated with hyperinsulinemia and may be a useful indicator of diabetes mellitus.

  • It may also be a marker of malignancy.

  • AN due to obesity, ...

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